PMID: 2118447Sep 1, 1990Paper

Acid-base disturbances in acute asthma

Chest
R D MountainS A Sahn

Abstract

The clinical features, arterial blood gases, and acid-base profile were examined in 229 consecutive episodes of acute asthma in 170 patients who required hospitalization. A simple respiratory alkalosis was the most common acid-base disturbance, occurring in 48 percent of the episodes. Metabolic acidosis, either alone or as part of a mixed disturbance, was noted in 28 percent. Of 60 episodes presenting with respiratory acidosis, 37 (62 percent) had a coexistent metabolic acidosis. Metabolic acidosis was more likely to occur in male subjects and in patients with evidence of more severe airflow obstruction. Patients with metabolic acidosis had an average anion gap of 15.8 mEq/L; these patients were more hypoxemic than those without metabolic acidosis and there was a significant inverse correlation between the anion gap and the degree of hypoxemia. We conclude that metabolic acidosis is a common finding in acute, severe asthma and suggest that the pathogenesis of lactic acidosis is multifactorial and includes contributions from lactate production by respiratory muscles, tissue hypoxia, and intracellular alkalosis.

References

Dec 1, 1987·Critical Care Medicine·D G OkrentD P Tashkin
May 1, 1972·Kidney International·A S Relman
Oct 1, 1972·Acta Physiologica Scandinavica·L Hermansen, I Stensvold
Jan 1, 1968·Respiration; International Review of Thoracic Diseases·J C MithoeferM S Karetzky
Jul 1, 1972·The Journal of Clinical Investigation·F J GennariW B Schwartz
May 9, 1968·The New England Journal of Medicine·E R McFadden, H A Lyons
Jan 16, 1969·The New England Journal of Medicine·G S ArbusW B Schwartz
Oct 1, 1983·The American Journal of Medicine·D AppelM H Williams
May 1, 1983·The American Journal of Medicine·S M Menitove, R M Goldring
Jan 1, 1983·Thorax·S FreedmanJ Moxham
Sep 1, 1981·Clinical Science·J R SuttonC J Toews
Jun 10, 1965·The New England Journal of Medicine·J C MITHOEFERM S KARETZKY

❮ Previous
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Citations

May 17, 2011·Clinical Reviews in Allergy & Immunology·Samuel LouieMark Avdalovic
Dec 19, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ejaz Yousef, Stephen J McGeady
May 17, 2000·Current Opinion in Pulmonary Medicine·T P Miller, R G Barbers
Jun 12, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·D Bohn, N Kissoon
Jan 2, 2007·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Pulin B KoulBalagangadhar R Totapally
Oct 2, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kathleen L MeertAshok P Sarnaik
Nov 9, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Desmond Bohn
Mar 22, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Antony E TobinJohn D Santamaria
May 25, 2005·Emergency Medicine Journal : EMJ·G J Rodrigo, C Rodrigo
May 13, 2008·International Archives of Medicine·Tonny V Veenith, Abigail Pearce
Jul 8, 2010·Italian Journal of Pediatrics·Kam-Lun HonPak-Cheung Ng
Nov 17, 2009·Drugs·Spyros A PapirisIraklis Tsangaris
Jun 27, 2013·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·I Federico Fernandez Nievas, Kanwaljeet J S Anand
Jun 3, 1998·Intensive Care Medicine·A RabbatJ Rochemaure
Aug 5, 2004·Critical Care Nursing Quarterly·Susan J Corbridge, Thomas C Corbridge
Feb 3, 2016·The American Journal of Emergency Medicine·Ali PourmandHamid Shokoohi
Nov 6, 2010·Chest·Rahul K MishraKenneth M Nugent
Aug 25, 2009·The Journal of Emergency Medicine·Barry BrennerAntoine Kazzi
Apr 16, 2008·The American Journal of Emergency Medicine·Ben C Creagh-Brown, Jonathan Ball
Nov 29, 2015·Emergency Medicine Clinics of North America·Salvador J Suau, Peter M C DeBlieux
Jul 25, 2009·Clinical Physiology and Functional Imaging·Tessa A C NizetHans Th M Folgering
May 26, 2004·La Revue de médecine interne·A Du-ThanhA Le Quellec
Feb 1, 1997·Annals of Emergency Medicine·A JagodaM M Joseph
Aug 21, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Guillermo A RaimondiHoracio J Adrogué
Nov 16, 2013·Clinical Reviews in Allergy & Immunology·Michael SchivoRichart W Harper
Mar 7, 2014·World Journal of Pediatrics : WJP·Christopher L CarrollCraig M Schramm
Aug 5, 2016·Hospital Pediatrics·James C McAvoy, Ashna Khurana
Jun 1, 1997·American Journal of Hematology·D W EssexT P Bradley
Jan 21, 2010·Journal of Intensive Care Medicine·Praveen Mannam, Mark D Siegel
Jun 20, 2018·BMJ Case Reports·Zain Sharif, Mazen Al-Alawi
Dec 9, 2003·Journal of Veterinary Internal Medicine·D BedeniceM R Paradis
Apr 28, 2019·Journal of Clinical Medicine·Ioannis VasileiadisAntonia Koutsoukou
Jul 5, 2011·CJEM·Reid McGonigle, Robert A Woods
Nov 19, 2014·Current Opinion in Pulmonary Medicine·Gustavo J Rodrigo

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