PMID: 2110804Apr 1, 1990Paper

Acid-base state of the preterm infant and the formulation of intravenous feeding solutions

Archives of Disease in Childhood
P MacMahonI Z Kovar

Abstract

An acidic intravenous source of phosphorus (Addiphos) was compared with dipotassium hydrogen phosphate in 25 preterm infants to study acid-base state. Eight infants were given either Addiphos or dipotassium hydrogen phosphate alternately for 48 hour periods and similar amounts of calcium and phosphorus were delivered. There were no significant differences in calcium and phosphorus intake, calcium and phosphate plasma concentrations, or acid-base state between study periods on the two solutions. Seventeen infants were given the two solutions alternately for 72 hour periods; Addiphos was used to increase the amounts of calcium and phosphorus being delivered. Calcium and phosphorus intake was decreased on dipotassium hydrogen phosphate, but Addiphos significantly increased calcium and phosphorus intake and plasma calcium and phosphate concentrations. It also lowered the pH of the urine and raised the titratable acidity. Acid-base state, however, was not significantly different. It is therefore possible to increase intake of calcium and phosphorus in preterm infants without causing a significant metabolic acidosis.

References

Oct 1, 1976·Journal of Pediatric Surgery·L L Leape, T Valaes
Apr 1, 1990·Archives of Disease in Childhood·P MacMahonI Z Kovar
Jun 6, 1987·Lancet·O Björkman, M Lindholm
May 1, 1986·Archives of Disease in Childhood·G Aiken, W Lenney
Nov 9, 1972·The New England Journal of Medicine·W C HeirdR W Winters

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Citations

Jan 1, 1992·Nutrition Research Reviews·J B Morgan, I Z Kovar
Jul 1, 1992·Archives of Disease in Childhood·J H Walter
Mar 1, 1991·Annals of Clinical Biochemistry·P D Mayne, I Z Kovar

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