PMID: 5894045Dec 1, 1965

Acid hydrolases of the rat uterus in relation to pregnancy, post-partum involution and collagen breakdown

The Biochemical Journal
J F Woessner

Abstract

1. The rat uterus contains acid cathepsin, beta-glucuronidase, beta-galactosidase, acid phosphatase and deoxyribonuclease II at concentrations comparable with those found in liver. Two non-hydrolytic uterine enzymes, cytochrome c oxidase and aspartate aminotransferase, display only 2-6% of the activity found in liver. 2. The concentrations of acid cathepsin and beta-glucuronidase are significantly decreased in pregnancy and increase 3-4-fold during post-partum involution. 3. The concentrations of beta-galactosidase and acid phosphatase are not decreased in pregnancy and increase only 2-3-fold during involution. 4. The concentrations of these four acid hydrolases increase linearly during the first 4 days post partum and reach their peak values at the same time that wet weight and collagen content fall to their lowest point. 5. The concentration of deoxyribonuclease is depressed in pregnancy but does not rise above normal in the post-partum period. 6. Only a small proportion of each hydrolytic activity can be isolated in the mitochondrial-lysosomal fraction of sucrose homogenates of the rat uterus. This proportion increases during involution. However, the extensive mitochondrial rupture occurring during homogenization indicates t...Continue Reading

Citations

Apr 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R I NicholsonM Davies
Aug 1, 1969·The Journal of Surgical Research·T N Salthouse, J A Williams
Apr 6, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·V V RyvniakA V Pelin
Jun 11, 2009·Bulletin of Experimental Biology and Medicine·V A ShkurupiyN N Dubinina
Mar 1, 1972·Journal of Dental Research·S Bazin, A Delaunay
Apr 5, 1974·Nature·J N Ryan, J F Woessner
May 4, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·V V RyvniakA V Pelin
Oct 3, 1977·European Journal of Biochemistry·H GeyerE G Afting
Aug 1, 1969·The Journal of Obstetrics and Gynaecology of the British Commonwealth·J C WoodR H Cowdell
May 1, 1968·Die Naturwissenschaften·P Bohley
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·F HenellH Glaumann
Jan 1, 1971·Histochemie. Histochemistry. Histochimie·H W Denker
Jun 1, 1968·Acta Medica Scandinavica·O WegeliusK Vainio
Jan 1, 1967·The British Journal of Nutrition·J BunyanD Robinson

Related Concepts

Acid Phosphatase
Cathepsins
Zyderm
Alkaline DNase
Galactosidase
Exo-beta-D-Glucuronidase
Lysosomes
Pregnancy, Animal
Subcellular Fractions
Uterus

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