Acid-induced increase in duodenal mucosal alkaline secretion in the rat involves the L-arginine/NO pathway

Acta Physiologica Scandinavica
M HolmL Fändriks

Abstract

Duodenal mucosal alkaline secretion increases in response to hydrochloric acid exposure. The tentative role of nitric oxide (NO) in the mediation of this response was investigated. The mucosal alkaline output by a duodenal segment was recorded by in situ titration in chloralose-anaesthetized rats. In some experiments the duodenal blood flow was estimated by laser-Doppler flowmetry. Exposure of the duodenum to acid (0.01 M HCl, 5 min) increased the alkaline secretion by approximately 85%. The NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 10 mg kg-1 intravenously or 0.3 mM intraluminally) blocked the secretory increment after mucosal acid exposure. Mean arterial pressure and basal alkaline secretion were markedly raised, whereas duodenal blood flow was decreased, when L-NAME was given intravenously (i.v.). Intraluminal (i.l.) administration left mean arterial pressure as well as duodenal blood flow unaltered, and the duodenal mucosal alkaline secretion was only slightly elevated. The stereoisomer NG-nitro-D-arginine methyl ester (D-NAME) had no effect on either basal or acid-induced duodenal alkaline output. In animals receiving L-arginine (10 mg kg-1 min-1 i.v., or 3 mM i.l.) and L-NAME, the acid exposure elici...Continue Reading

Citations

Apr 12, 2000·Acta Physiologica Scandinavica·J SnyggA Aneman
Jul 25, 2000·Acta Physiologica Scandinavica·S HellgrenO Nylander
Aug 4, 2005·Upsala Journal of Medical Sciences·Markus Sjöblom
Apr 5, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·L OlbeA M Svennerholm
Jul 26, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·S P RaoV S Pratha
Aug 13, 1999·The American Journal of Physiology·Y AkibaJ D Kaunitz
Jan 14, 1999·The American Journal of Physiology·Y Akiba, J D Kaunitz

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