Acid-labile boronate-bridged dextran-bortezomib conjugate with up-regulated hypoxic tumor suppression

Chemical Communications : Chem Comm
Weiguo XuXuesi Chen

Abstract

An acid-labile dextran-bortezomib conjugate (Dex-BTZ), i.e., a macromolecularized proteasome inhibitor, is synthesized by a boron esterification reaction. The prodrug exhibits intracellular acidity-accelerated BTZ release, and up-regulated inhibition efficacies toward hypoxic tumor in vitro and in vivo through both NF-κB- and ERS-mediated apoptosis signaling pathways.

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Nov 22, 2014·ACS Applied Materials & Interfaces·Diankui SunXuesi Chen
Feb 2, 2016·Chemical Communications : Chem Comm·James LazarovitsWarren C W Chan

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Citations

Nov 1, 2016·Molecular Pharmaceutics·Di LiXuesi Chen
Jan 10, 2017·ACS Applied Materials & Interfaces·Yuhao ZhengXuesi Chen
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Xiangru FengJianxun Ding
Jan 9, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Kexin ShenXuesi Chen
May 27, 2016·Chemical Communications : Chem Comm·Thavasyappan ThambiDoo Sung Lee
Sep 24, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Eda Rami ReddyNarayana Nagesh
Jan 12, 2019·Chemical Communications : Chem Comm·Yu-Hui ZhangYu Liu
Mar 23, 2019·Chemical Communications : Chem Comm·Yin LiuLin Zhu
Jul 31, 2019·Macromolecular Bioscience·Xinghui SiZhaohui Tang
Jul 15, 2015·Macromolecular Bioscience·Xiaofei ChenXuesi Chen
Jan 28, 2020·Anti-cancer Agents in Medicinal Chemistry·Mitra KoraniAmirhossein Sahebkar
Sep 29, 2020·Beilstein Journal of Organic Chemistry·Patrizia AndreozziBarbara Richichi
May 5, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yiting QiaoHangxiang Wang
Sep 12, 2019·Advanced Science·Xiangru FengXuesi Chen
Jan 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinyu ZhangJun Wu
Aug 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Di LiXuesi Chen

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