PMID: 596663Oct 1, 1977Paper

Acid phosphatase of the rat epididymis. III. Histochemical and biochemical responses in experimental conditions

V Nikkanen, T Vanha-Perttula


The specific activities of three acid phosphatases were followed in the epididymis of growing rats. All activities were constantly rising but revealed two steeper parts probably corresponding to the increase of androgen secretion and the arrival of spermatozoa in the epididymis. Simultaneously an increase in the histochemical staining was obtained in all epididymal segments. Both biochemical and histochemical studies showed that castration reduced the activity of all acid phosphatases and this could be restored with testosterone-estradiol treatment. Estradiol had no effect on the activities in the castrated animal, but in the normal animal it caused an elevation of Enzyme I activity. In the histochemical study estradiol seemed to restore the acid phosphatase activity. Enzyme I reacted slower than the others to both castration and hormone treatment. Increased elimination caused by ligation of the epididymis caused a reduction in the activity of all enzymes within four days. It was greatest in the area of the corpus. This study, however, rendered no further elucidation for the assumption that acid phosphatases participate in the elimination of excessive and defective spermatozoa.


Jun 1, 1969·Biology of Reproduction·J Martan
Apr 1, 1970·Journal of Reproduction and Fertility·A C Allison, E F Hartree
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·C J Flickinger
Jul 1, 1967·Fertility and Sterility·J D RousselC R Austin
Jun 1, 1969·Biology of Reproduction·M C Orgebin-Crist
Jun 1, 1970·Endocrinology·D W KnorrM B Lipsett
Jun 16, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·L Nicander
Aug 15, 1967·Life Sciences·B Hellström, L Nicander
Nov 20, 1952·Annals of the New York Academy of Sciences·K E MASON, S L SHAVER
Jan 1, 1960·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J M ALLEN, R L HUNTER
Mar 1, 1964·The Anatomical Record·M H BURGOS
Apr 1, 1965·Journal of Reproduction and Fertility·P GADDUM, T D GLOVER

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