PMID: 109016Jun 1, 1979

Acid secretion by isolated primate gastric mucosa

The American Journal of Physiology
P K Rangachari

Abstract

Pentagastrin, histamine, and acetylcholine stimulated acid secretion in the isolated rhesus (Macaca mulatta) gastric mucosa. The potencies were in the order pentagastrin greater than histamine greater than acetylcholine. However, histamine was more effective, the calculated maximal response being twice as great as for the other two agonists. Metiamide inhibited acid secretion induced by both histamine and pentagastrin. Whereas the inhibition of histamine by metiamide was surmountable, that of pentagastrin was not. Atropine inhibited the response to acetylcholine. Even in higher doses, atropine had no effect on histamine. With stimulation, transmucosal potential differences and resistances decreased; the changes were reversed on inhibition.

References

Jan 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·S E SjöstrandL Olbe
Jan 1, 1975·The Journal of Physiology·J G ForteT E Machen
Feb 1, 1976·Acta Physiologica Scandinavica·T Berglindh, K J Obrink
Apr 1, 1974·The American Journal of Physiology·R L ShoemakerG Sachs
Apr 1, 1969·The American Journal of Digestive Diseases·S KitaharaC A Hogben
Oct 1, 1970·The American Journal of Physiology·R L ShoemakerG Sachs
May 20, 1958·The Journal of General Physiology·R P DURBIN, E HEINZ
Sep 1, 1960·The American Journal of Physiology·I N MARKSH SHAY
Jan 25, 1965·Biochimica Et Biophysica Acta·J T CUMMINS, B E VAUGHAN

Related Concepts

Acetylcholine Sulfate (1: 1)
Anthropoidea
Dose-Response Relationship, Drug
Gastric Juice
Structure of Pyloric Gland
Ceplene
Macaca mulatta
Peptavlon
Stomach

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