Acid-sensing ion channel 3 or P2X2/3 is involved in the pain-like behavior under a high bone turnover state in ovariectomized mice

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Kumiko KanayaToshihiko Yamashita

Abstract

We have recently demonstrated that pathological changes leading to increased bone resorption by osteoclast activation are related to the induction of pain-like behavior in ovariectomized (OVX) mice. In addition, bisphosphonate and the antagonist of transient receptor potential vanilloid type 1 (TRPV1), an acid-sensing nociceptor, improved the threshold value of pain-like behaviors accompanying an improvement in the acidic environment in the bone tissue based on osteoclast inactivation. The aim of this study was to evaluate the effect of (i) an inhibitor of vacuolar H(+) -ATPase, known as an proton pump, (ii) an antagonist of acid-sensing ion channel (ASIC) 3, as another acid-sensing nociceptor, and (iii) the P2X2/3 receptor, as an ATP-ligand nociceptor, on pain-like behavior in OVX mice. This inhibitor and antagonists were found to improve the threshold value of pain-like behavior in OVX mice. These results indicated that the skeletal pain accompanying osteoporosis is possibly associated with the acidic microenvironment and increased ATP level caused by osteoclast activation under a high bone turnover state.

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Citations

Feb 7, 2016·Bone·Cecília J AlvesMeriem Lamghari
Mar 5, 2016·Current Opinion in Pharmacology·Charlotte Ørsted FrostAnne-Marie Heegaard
Jul 20, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takayuki DohkeToshihiko Yamashita
Oct 20, 2018·Biomedical Research·Yuji KasukawaYoichi Shimada
Dec 20, 2017·Spine Surgery and Related Research·Sumihisa OritaSeiji Ohtori
Jul 12, 2019·The Journal of Pharmacy and Pharmacology·Jing WangJing Wang
Feb 6, 2020·Journal of Bone and Mineral Metabolism·Koji IbeToshihiko Yamashita
Mar 20, 2018·Pflügers Archiv : European journal of physiology·Miyuki Kuno
Jul 14, 2020·Journal of Bone and Mineral Metabolism·Kenta KiyomotoToshihiko Yamashita
Sep 29, 2017·Frontiers in Neurology·Jason J Ivanusic
Sep 19, 2019·BioMed Research International·Ching-Yu LeeKuan-Der Lee
Jul 28, 2019·British Journal of Pharmacology·Thomas M Tzschentke
Sep 22, 2020·European Journal of Pain : EJP·Larissa de ClauserShafaq Sikandar
Jan 19, 2021·Injury·Hikaru HayakawaToshihiko Yamashita

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