Acid Sphingomyelinase-Ceramide System in Bacterial Infections

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Cao LiZhigang Zhao

Abstract

Acid sphingomyelinase hydrolyzes sphingomyelin to ceramide and phosphorylcholine. Ceramide molecules spontaneously interact with each other and generate ceramide-enriched membrane domains. These ceramide-enriched domains further fuse, forming large ceramideenriched platforms that participate in the organization of receptors and in the amplification of signaling molecules. Recent studies have suggested several bacteria and bacterial toxins that stimulate the activation and the translocation of acid sphingomyelinase, which leads to the release of ceramide. The acid sphingomyelinase/ceramide system also regulates the internalization of bacteria into the host cell, the subsequent cytokine release, inflammatory response, and initiation of host cell apoptosis. In addition, ceramide has been implicated in the fusion of phagosomes and lysosomes upon bacterial infection. Thus, this system modulates the reorganization of cell membrane receptors and intracellular signaling molecules during bacteria-host interactions. The acid sphingomyelinase and ceramide system may thus serve as a novel therapeutic target for treating infections.

Citations

Apr 17, 2019·International Journal of Molecular Sciences·Michelle A Erickson, William A Banks
Oct 15, 2019·Frontiers in Cell and Developmental Biology·Tobias C Kunz, Vera Kozjak-Pavlovic
Dec 24, 2019·Frontiers in Cell and Developmental Biology·Johannes M F G AertsR G Boot
Oct 21, 2020·Scientific Reports·Igor de la AradaJosé-Luis R Arrondo
Dec 18, 2019·Biochimica Et Biophysica Acta. Biomembranes·Cristiane R ZuconelliMerel J W Adjobo-Hermans
Feb 9, 2021·Frontiers in Medicine·Ralf A Claus, Markus H Graeler
Apr 23, 2021·Cell Communication and Signaling : CCS·Clovis H T SeumenChristof R Hauck
Jan 9, 2022·Molecular Psychiatry·Yaeko HashimotoKenji Hashimoto

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