Acidianus Tailed Spindle Virus: a New Archaeal Large Tailed Spindle Virus Discovered by Culture-Independent Methods

Journal of Virology
Rebecca HochsteinMark J Young

Abstract

The field of viral metagenomics has expanded our understanding of viral diversity from all three domains of life (Archaea, Bacteria, and Eukarya). Traditionally, viral metagenomic studies provide information about viral gene content but rarely provide knowledge about virion morphology and/or cellular host identity. Here we describe a new virus, Acidianus tailed spindle virus (ATSV), initially identified by bioinformatic analysis of viral metagenomic data sets from a high-temperature (80°C) acidic (pH 2) hot spring located in Yellowstone National Park, followed by more detailed characterization using only environmental samples without dependency on culturing. Characterization included the identification of the large tailed spindle virion morphology, determination of the complete 70.8-kb circular double-stranded DNA (dsDNA) viral genome content, and identification of its cellular host. Annotation of the ATSV genome revealed a potential three-domain gene product containing an N-terminal leucine-rich repeat domain, followed by a likely posttranslation regulatory region consisting of high serine and threonine content, and a C-terminal ESCRT-III domain, suggesting interplay with the host ESCRT system. The host of ATSV, which is most ...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Oct 1, 1994·Trends in Biochemical Sciences·B Kobe, J Deisenhofer
Feb 28, 1998·Nucleic Acids Research·S L SalzbergO White
May 29, 2000·Trends in Genetics : TIG·P RiceA Bleasby
Oct 29, 2002·Current Biology : CB·J Nicholas BetleyJames O Deshler
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·George RiceMark Young
May 8, 2004·Molecular Microbiology·Oleg Rodionov, Michael Yarmolinsky
May 26, 2005·Protein Expression and Purification·F William Studier
Jun 28, 2005·Nucleic Acids Research·Johannes SödingAndrei N Lupas
Dec 13, 2006·Journal of Bacteriology·Silvia Berkner, Georg Lipps
Dec 19, 2006·Virology·Adam J Clore, Kenneth M Stedman
Jun 1, 2007·Nucleic Acids Research·Ibtissem GrissaChristine Pourcel
Feb 1, 2008·Molecular Biology and Evolution·Gipsi Lima-MendezRaphaël Leplae
Apr 15, 2008·Cellular and Molecular Life Sciences : CMLS·J BellaS C Lovell
Apr 29, 2008·Applied and Environmental Microbiology·Thomas SchoenfeldDavid Mead
Mar 21, 2009·Nature Protocols·Rebecca V ThurberForest Rohwer
Sep 29, 2009·Trends in Microbiology·Rachel Y Samson, Stephen D Bell
Jun 22, 2010·Environmental Microbiology·Fernando SantosJosefa Antón
May 25, 2011·Extremophiles : Life Under Extreme Conditions·Xiao-Yan YouRoger A Garrett
Sep 2, 2011·Genome Research·Samuel MinotFrederic D Bushman
Mar 1, 2012·Current Biology : CB·Oliver Schmidt, David Teis
Mar 24, 2012·Current Opinion in Virology·Karyna Rosario, Mya Breitbart
Mar 24, 2012·Current Opinion in Virology·John L MokiliBas E Dutilh
Apr 6, 2012·PloS One·Inmaculada Garcia-HerediaFrancisco Rodriguez-Valera
Dec 12, 2012·Journal of Bacteriology·David M KristensenEugene V Koonin
Jan 30, 2013·Biochemical Society Transactions·David PrangishviliMart Krupovic
Feb 15, 2013·Nature·Yanlin ZhaoStephen J Giovannoni
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jamie C SnyderMark J Young
Feb 1, 2011·Environmental Microbiology Reports·Cristina MoraruRudolf Amann
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ilnam KangJang-Cheon Cho
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Samuel MinotFrederic D Bushman
Jul 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Karin HolmfeldtMatthew B Sullivan
Sep 3, 2013·Applied and Environmental Microbiology·Joanne B EmersonJillian F Banfield

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Citations

Oct 30, 2016·Nucleic Acids Research·Ana Laura GrazziotinDavid M Kristensen
Mar 3, 2018·Genes·Jacob H Munson-McGeeMark J Young
Nov 11, 2017·Nature Reviews. Microbiology·David PrangishviliMart Krupovic
Oct 14, 2017·The ISME Journal·Daniel R ColmanEric S Boyd
Jun 8, 2018·The Journal of General Virology·David Prangishvili Ictv Report Consortium
Apr 8, 2018·Applied and Environmental Microbiology·Maximiliano J Amenabar, Eric S Boyd
Apr 21, 2017·Journal of Virology·Ying LiuDavid Prangishvili
Aug 14, 2020·PLoS Pathogens·Jennifer Wirth, Mark Young
May 12, 2018·Environmental Microbiology·Maximiliano J AmenabarEric S Boyd
Feb 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Rebecca HochsteinC Martin Lawrence
Jun 27, 2019·Current Opinion in Virology·Ross HartmanCharles Martin Lawrence
Apr 6, 2021·Environmental Microbiology·Yaiza M CastilloMarta Sebastián
Aug 1, 2021·Nature Communications·Janina RahlffAlexander J Probst

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