Oct 1, 1975

Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data

Arzneimittel-Forschung
J G LombardinoE H Wiseman

Abstract

Fifteen acidic antiinflammatory agents, for which some clinical data have previously been published, have been examined for their potency in the carrageenan-induced rat foot edema test, and for their acidity (pKa) and partition coefficients. Published serum half-life data and daily clinical (anti-arthritic) dose have been tabulated for these drugs and correlations between these various parameters are discussed. The rat foot edema carrageenan test has proved to be a fairly reliable predictor of clinical dose for most acidic antiinflammatory agents of moderate serum half-life.

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Mentioned in this Paper

Anti-Inflammatory Agents
Anasarca
lambda-Carrageenan
Hindlimb
Half-Life
Dose-Response Relationship, Drug
Hydrogen-Ion Concentration
Medicinal Plants Testing, Preclinical
Edema
Canis familiaris

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