Acidic FGF and FGF receptors are specifically expressed in neurons of developing and adult rat dorsal root ganglia

The European Journal of Neuroscience
C OelligR F Pettersson

Abstract

Employing complementary technical approaches, we have studied the expression of acidic fibroblast growth factor (aFGF) and FGF receptors in rat dorsal root ganglia. The results clearly showed that within spinal nerves aFGF and two high-affinity FGF receptors, FGFR-1 and FGFR-2, were prominently expressed in neurons, while expression in Schwann cells was undetectable. FGFR-3 and FGFR-4 were not expressed in dorsal root ganglia. Acidic FGF mRNA was detected in the majority of dorsal root ganglion neurons, including all size classes: FGFR-1 and FGFR-2 transcripts were only detected in subpopulations of mainly large and medium size neurons. In subcellular fractionation studies on dorsal root ganglion and spinal root tissue, aFGF was recovered in the soluble fraction and was thus not tightly associated with neuronal membranes. During development FGFR-1 and FGFR-2 mRNAs were found to be present at all stages examined (embryonic days 15-21 and postnatal days 1-120). Acidic FGF mRNA and protein were first detected at embryonic day 18, and their expression then increased progressively up to postnatal levels. In cultures of dorsal root ganglion neurons derived from day 15 embryos, aFGF expression was first detected 3 days after plating. ...Continue Reading

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Citations

Oct 1, 1995·Current Opinion in Neurobiology·S B McMahon, J V Priestley
Feb 6, 2004·Life Sciences·Liang-Ming LeeI-Hui Lee
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·U PirvolaJ Ylikoski
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Sep 1, 2015·Neuroscience Letters·Fausto Pierdoná GuzenJeferson Sousa Cavalcante
Dec 14, 2011·The Journal of Investigative Dermatology·Mina Yaar, Hee-Young Park
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May 12, 2021·Neuropathology and Applied Neurobiology·Lucie ValekIrmgard Tegeder

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