PMID: 2502994Jul 1, 1989Paper

Acidic glycosaminoglycans in human atherosclerotic cerebral arterial tissues

Atherosclerosis
K Murata, Y Yokoyama

Abstract

The glycosaminoglycan (GAG) content of normal and atherosclerotic areas of cerebral arterial tissue isolated from human males was measured. The main trunk and distal branches of the arteries were obtained at autopsy on 12-89-year-old Japanese subjects. The GAG components were analysed by high-performance liquid chromatography (HPLC) after enzymatic digestion, using specific GAG lyases. Both total GAGs and water content were lower in the diseased arteries than those in the normal state. In contrast, the reverse was noted for the lipid content. The main GAG component of the normal cerebral arteries was heparan sulfates (HS), comprising half the total GAGs, followed by dermatan sulfate (DS) and chondroitin 6-sulfate (Ch-6S) constituting 1/5 to 1/9 the total GAGs. Chondroitin 4-sulfate (Ch-4S) comprised approx. 1/10 the total GAGs. Oversulfated chondroitin sulfate isomers were detected as novel peaks of the chondroitin sulfate types G, B, E and H on HPLC analysis. Small amounts of hyaluronic acid (HA) and chondroitin were also detected. The total GAG content decreased with severity of atherosclerosis. The content and proportions of HS to the total GAGs decreased remarkably, and those of Ch-4S, HA and chondroitin showed a moderate d...Continue Reading

References

Aug 1, 1976·The Journal of Clinical Investigation·R L StevensK Schmid
Oct 1, 1976·Atherosclerosis·K Murata, K Nakazawa
Dec 1, 1987·Scandinavian Journal of Clinical and Laboratory Investigation·T C LaurentD Ytterberg
Sep 1, 1967·Journal of Atherosclerosis Research·V KumarJ P Strong
May 6, 1969·Biochimica Et Biophysica Acta·T HaradaT Furuhashi
Jul 1, 1971·Atherosclerosis·K Murata, Y Oshima
Jan 1, 1974·Connective Tissue Research·K MurataT Okuyama
Jan 1, 1974·Gerontologia Clinica·K Nakazawa, K Murata
Nov 1, 1968·Journal of Atherosclerosis Research·K MurataK Okubo
Sep 1, 1966·Journal of Biochemistry·Y KawaiK Anno
Jan 1, 1984·Stroke; a Journal of Cerebral Circulation·J P Whisnant
Mar 1, 1984·Stroke; a Journal of Cerebral Circulation·M Kotila
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR

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Citations

Sep 1, 1997·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·P GutierrezT N Wight
Jul 4, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C OsterholmH Ekberg
Apr 1, 1994·The Journal of Pharmacy and Pharmacology·M NoaR Más
Dec 1, 1990·Matrix : Collagen and Related Research·G M CherchiG De Luca
Mar 31, 2012·Biochemistry Research International·Antonio CiglianoMarilena Formato
Apr 3, 2015·Journal of Diabetes Research·Paola MorettoDavide Vigetti
May 1, 1999·Archives of Biochemistry and Biophysics·R AlbertiniP M Abuja
Jun 12, 2004·The Journal of Biological Chemistry·Yoshiyuki YasudaDieter Brömme
Mar 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Vidya V KunjathoorRenée C LeBoeuf
May 1, 1992·Journal of Neurosurgery·W T CouldwellM C Kuppner
Dec 14, 2007·The Journal of Biological Chemistry·Davide VigettiAlberto Passi
Jun 16, 2021·Molecular Biology Reports·María M Adeva-AndanyRaquel Funcasta-Calderón

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