PMID: 36462Apr 1, 1979

Acidic metabolites of delta1-tetrahydrocannabinol isolated from rabbit urine

The Journal of Pharmacy and Pharmacology
M NordqvistS Agurell

Abstract

The in vivo metabolism of delta1-tetrahydrocannabinol (delta1-THC) was investigated in the rabbit after i.v. administration. Thirteen acidic metabolites were isolated from rabbit urine and identified by gas chromatography-mass spectrometry and by proton magnetic resonance spectroscopy. One additional metabolite was tentatively identified. All but three were new metabolites and all but one were oxidized in the pentyl side chain. The metabolites included dicarboxylic acids, monocarboxylic acids and mono- or dihydroxylated derivatives thereof. However, the dicarboxylic acid metabolites were the most prominent.

Citations

Oct 1, 1976·The Journal of Pharmacy and Pharmacology·B R MartinW D Paton
Aug 1, 1977·The Journal of Pharmacy and Pharmacology·D J HarveyW D Paton
Sep 1, 1978·The Journal of Pharmacy and Pharmacology·A W YisakS Agurell
Jun 25, 1975·Journal of the American Chemical Society·C G PittD L Williams
May 15, 1975·Biochemical Pharmacology·Z Ben-Zvi, S Burstein
May 26, 1976·Journal of Chromatography·K Fonseka, M Widman
Jun 1, 1974·The Journal of Pharmacy and Pharmacology·M NordqvistI M Nilsson
Nov 1, 1972·Journal of the American Chemical Society·O GurnyR W Kierstead
Apr 1, 1974·Biochemical Pharmacology·M WidmanF Sandberg
Jun 3, 1970·Journal of the American Chemical Society·M E WallH D Christensen
Aug 26, 1970·Journal of the American Chemical Society·R A ArcherN L Allinger
Jun 5, 1970·Science·I M NilssonM Wahlqvist
Apr 1, 1970·Biochemical Pharmacology·S AgurellF Sandberg

Related Concepts

Metabolic Process, Cellular
Urine
Tetrahydrocannabinol
Derivatives
DLK1 gene
Gas Chromatography-Mass Spectrometry
Dicarboxylic Acids
Mass Spectrometry
Metabolic Pathway
DLK1 wt Allele

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