PMID: 8612792Mar 25, 1996Paper

Acidic phospholipids inhibit the phospholipase D activity of rat brain neuronal nuclei

FEBS Letters
J N KanferL Freysz

Abstract

An oleate dependent form of phospholipase D is present in rat brain neuronal nuclei and both the hydrolytic and transphosphatidylation activities measured. Several acidic phospholipids were found to inhibit this activity in a dose dependent manner. The IC50 values varied from 3.5 microM for PIP2 to 200 microM for phosphatidic acid. The hydrolysis of PIP2 by phospholipase C would be expected to result in the disinhibition of the oleate dependent phospholipase D activity.

References

Jul 1, 1991·Molecular and Cellular Endocrinology·C J HedeskovK Capito
Feb 13, 1987·Biochemical and Biophysical Research Communications·L Gustavsson, C Alling
Jan 1, 1985·Archives of Biochemistry and Biophysics·M Nemat-Gorgani, J E Wilson
Jul 17, 1973·Biochemical and Biophysical Research Communications·M Saito, J Kanfer
Aug 1, 1982·Journal of Neurochemistry·R Chalifour, J N Kanfer

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Citations

Jun 20, 1997·The Journal of Biological Chemistry·J H Exton
Apr 16, 1998·Biochemical and Biophysical Research Communications·S Y LeeM U Choi
May 9, 2001·Biochimica Et Biophysica Acta·L CoccoF A Manzoli
Aug 4, 1999·Molecular and Cellular Endocrinology·A M StrandH S Hansen
Jun 1, 2000·Advances in Enzyme Regulation·N M MaraldiF A Manzoli
Aug 15, 2002·Plant Physiology·Shea L Austin-Brown, Kent D Chapman

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