Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion

International Immunopharmacology
Sang-Bae HanHwan Mook Kim

Abstract

The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers. Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it has no direct effect on cancer cell growth. In addition, we found that PL increased macrophage NO production. These results suggest that PL has two antimetastatic functions, i.e., it acts as an immunopotentiator and as a direct inhibitor of cancer cell adhesion.

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Citations

Apr 3, 2012·The International Journal of Biochemistry & Cell Biology·Xiangyang PanJunxia Chen
Sep 5, 2012·Carbohydrate Polymers·Aizhen ZongFengshan Wang
Jul 26, 2012·International Journal of Biological Macromolecules·Tao XinGuangjie Sui
Feb 17, 2015·International Journal of Microbiology·María Elena ValverdeOctavio Paredes-López
May 1, 2010·Experimental and Therapeutic Medicine·Daniel Sliva
Feb 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renjie LiuGregory A Hudalla
Aug 7, 2012·Food & Function·Lu RenYacine Hemar
Feb 26, 2008·Experimental Biology and Medicine·Andrea T BorchersM Eric Gershwin
Dec 29, 2020·Nutrition and Cancer·Anley Teferra Kiddane, Gun-Do Kim
May 22, 2017·International Journal of Biological Macromolecules·Yandong ZhangChunshui Liu
Apr 10, 2018·Carbohydrate Polymers·Shayane da Silva MilhoriniMarcello Iacomini

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