Acidic preconditioning protects against ischemia-induced brain injury

Neuroscience Letters
Chen-hui ZhangZhong Chen

Abstract

Ischemic preconditioning protects against cerebral ischemia. Recent investigations indicated that acidic preconditioning (APC) protects against ischemia-induced cardiomyocytes injury. However, it is not clear whether APC can protect against cerebral ischemia. To address this issue, C57BL/6 mice were exposed 3 times at 10-min intervals to a normoxic atmosphere containing 20% CO(2) for 5 min before being further subjected to bilateral common carotid artery occlusion. APC reversed the ischemia-induced brain injury as revealed by improved performance in passive avoidance experiments and decreased neuron loss in the hippocampal CA1 region. Consistently, both APC-treated brain slices and primary cultured neurons were more resistant to oxygen-glucose-deprivation (OGD)-induced injury, in a pH- and time-dependent manner, as revealed by reversed cell/tissue viability. In addition, the APC treatment prevented OGD-induced mitochondrial transmembrane potential loss and apoptosis, which was inhibited by the mitochondrial permeability transport pore opener atractyloside. Taken together, these findings indicated that APC protects against ischemia-induced neuronal injury. The beneficial effects may be attributed, at least in part, to decreased ...Continue Reading

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Citations

Jun 30, 2012·Neuroscience Letters·Yury Ladilov
Dec 17, 2014·CNS Neuroscience & Therapeutics·Zhe ShenZhong Chen
Mar 18, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Pierre-Louis LegerChristiane Charriaut-Marlangue
Apr 26, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stine F PedersenLuis A Pardo
Nov 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yan-Ying FanZhong Chen
Mar 29, 2019·ACS Chemical Neuroscience·Radhika KesharwaniPallab Bhattacharya
Oct 5, 2021·Molecular Neurobiology·Jeff EhresmanPaul A Nyquist

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