Acidosis, hypoxia and bone

Archives of Biochemistry and Biophysics
Timothy R Arnett

Abstract

Bone homeostasis is profoundly affected by local pH and oxygen tension. It has long been recognised that the skeleton contains a large reserve of alkaline mineral (hydroxyapatite), which is ultimately available to neutralise metabolic H(+) if acid-base balance is not maintained within narrow limits. Bone cells are extremely sensitive to the direct effects of pH: acidosis inhibits mineral deposition by osteoblasts but it activates osteoclasts to resorb bone and other mineralised tissues. These reciprocal responses act to maximise the availability of OH(-) ions from hydroxyapatite in solution, where they can buffer excess H(+). The mechanisms by which bone cells sense small pH changes are likely to be complex, involving ion channels and receptors in the cell membrane, as well as direct intracellular effects. The importance of oxygen tension in the skeleton has also long been known. Recent work shows that hypoxia blocks the growth and differentiation of osteoblasts (and thus bone formation), whilst strongly stimulating osteoclast formation (and thus bone resorption). Surprisingly, the resorptive function of osteoclasts is unimpaired in hypoxia. In vivo, tissue hypoxia is usually accompanied by acidosis due to reduced vascular perf...Continue Reading

References

Dec 1, 1978·Journal of Cellular Physiology·T R BradleyM Rosendaal
Jan 1, 1991·Kidney International·J Green, C R Kleeman
Jun 1, 1989·The American Journal of Physiology·S M Sims, S J Dixon
Jul 1, 1987·The American Journal of Physiology·P A Hofmann, F Fuchs
Jul 1, 1986·Endocrinology·T R Arnett, D W Dempster
Jan 27, 1984·European Journal of Pharmacology·H H WangP K Pang
Aug 1, 1982·The American Journal of Medicine·J CunninghamS E Papapoulos
Jun 23, 1994·The New England Journal of Medicine·A SebastianR C Morris
Jan 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L Frassetto, A Sebastian
Oct 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U S Barzel
Mar 7, 1997·The Journal of Biological Chemistry·T NordströmS Grinstein
Aug 26, 1998·The Journal of Physiology·M S MorrisonT R Arnett
Sep 9, 1998·The American Journal of Physiology·T OokawaraH Ohno
Sep 14, 1999·The American Journal of Physiology·J S DoddT S Gross
Dec 30, 1999·Journal of Leukocyte Biology·J S LewisC E Lewis
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G S Belinsky, A H Tashjian
May 11, 2000·Annals of Plastic Surgery·D S SteinbrechM T Longaker
Oct 18, 2000·Bone·A HoebertzT R Arnett
Dec 21, 2000·American Journal of Physiology. Cell Physiology·J A SpectorM T Longaker
Jun 26, 2001·The Journal of Surgical Research·S M WarrenM T Longaker
Jul 12, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T BuclinP Burckhardt
Jul 18, 2001·Journal of Applied Physiology·T J WetterJ A Dempsey
Jan 11, 2002·Blood·Jonathan S HarrisonPersis Bandari
Jan 18, 2002·Journal of Applied Physiology·S RatelM Bedu
Feb 23, 2002·Clinical Orthopaedics and Related Research·Susan A BloomfieldMichael D Delp
Jun 29, 2002·Molecular and Cellular Endocrinology·J H ParkH S Baek
Oct 17, 2002·Vascular Pharmacology·Richard E White
Mar 12, 2003·Cell·Thorsten CramerRandall S Johnson
May 27, 2003·Journal of Cellular Physiology·Timothy R ArnettSajeda Meghji
Sep 5, 2003·Nature·Marie-Gabrielle LudwigKlaus Seuwen
Feb 1, 1960·The Journal of Bone and Joint Surgery. British Volume·J TRUETA, J D MORGAN
Jun 3, 2004·Journal of Cellular Physiology·Christopher OntiverosLaura R McCabe
Jul 21, 2004·The Journal of Biological Chemistry·Ali SalimMichael T Longaker
Oct 1, 2004·The British Journal of Radiology·N RaghunandR J Gillies
Dec 14, 2004·Calcified Tissue International·Dincer YildizdasGuler Ozer
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Svetlana V KomarovaS Jeffrey Dixon

❮ Previous
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Citations

Aug 15, 2013·Calcified Tissue International·Ana Maria S SimãoPietro Ciancaglini
Jun 12, 2013·Calcified Tissue International·Shoko TakeuchiAkifumi Togari
Jul 12, 2011·Journal of Materials Science. Materials in Medicine·Anika JonitzRainer Bader
Aug 15, 2013·Purinergic Signalling·Geoffrey BurnstockIsabel R Orriss
Apr 3, 2012·Sleep & Breathing = Schlaf & Atmung·Hulya UzkeserKorhan Kilic
Aug 3, 2012·Nutrition & Metabolism·Ian Forrest Robey
Nov 16, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Stefania MarianiLucio Gnessi
Jan 23, 2014·Tissue Engineering. Part a·Laurent-Emmanuel MonfouletDelphine Logeart-Avramoglou
Dec 6, 2014·International Journal of Molecular Sciences·Feng-Lai YuanJian Dong
Jan 30, 2016·Cytokine·Sahar Hiram-BabYankel Gabet
Jul 16, 2015·Transfusion·Symeon TournisNikolaos Papaioannou
Jun 8, 2012·European Journal of Cell Biology·Lucie BrissonSébastien Roger
Jul 10, 2012·Experimental Cell Research·Jessal J PatelTimothy R Arnett
Apr 21, 2012·Maturitas·John C Stevenson
Jun 8, 2013·Stem Cells·Sami PalomäkiPeppi Koivunen
Dec 14, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pia Rosgaard JensenJean-Marie Delaissé
Jun 19, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lynne J HockingMiep H Helfrich
Sep 20, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Helene Bjoerg KristensenJean-Marie Delaisse
Feb 3, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christine M SwansonEric S Orwoll
Mar 13, 2014·International Journal of Cancer. Journal International Du Cancer·Richard BachelierPhilippe Clézardin
Nov 6, 2015·International Journal of Biomaterials·Claudia BergemannBarbara Nebe
Sep 3, 2013·Respiratory Physiology & Neurobiology·Marta TorresRamon Farré
Jan 17, 2012·Biochemical and Biophysical Research Communications·Heejin AhnDaewon Jeong
Jul 25, 2015·Journal of Bone and Mineral Metabolism·Rabia Terzi, Zahide Yılmaz
May 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-C YounS-M Kang
Apr 23, 2015·Expert Reviews in Molecular Medicine·Justin DragerJake Barralet
Jul 1, 2015·Journal of Endocrinological Investigation·F CeccatoC Scaroni
May 27, 2014·The British Journal of Oral & Maxillofacial Surgery·Anson JoseAjoy Roychoudhury
Feb 11, 2015·Biochemical and Biophysical Research Communications·Asuka OkitoIkuo Morita
Nov 14, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Olli-Pekka LappalainenGeorge K Sándor
May 4, 2016·Journal of Tissue Engineering and Regenerative Medicine·Hee-Kyoung KimHyun-Kwang Seok
Jul 26, 2016·Frontiers in Physiology·Feng-Lai YuanJian Dong
Aug 10, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A D DedeS Tournis
Oct 26, 2016·Journal of Endodontics·Athina M MavridouPaul Lambrechts
Nov 30, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T NoguchiH Yoshikawa

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