Acidosis Promotes Metastasis Formation by Enhancing Tumor Cell Motility

Advances in Experimental Medicine and Biology
A RiemannOliver Thews

Abstract

The tumor microenvironment is characterized by hypoxia, acidosis as well as other metabolic and biochemical alterations. Its role in cancer progression is increasingly appreciated especially on invasive capacity and the formation of metastasis. The effect of acidosis on metastasis formation of two rat carcinoma cell lines was studied in the animal model. In order to analyze the pH dependency of different steps of metastasis formation, invasiveness, cell adhesion and migration of AT-1 prostate cancer cells as well as possible underlying cell signaling pathways were studied in vitro. Acidosis significantly increased the formation of lung metastases of both tumor cell lines in vivo. In vitro, extracellular acidosis neither enhanced invasiveness nor affected cell adhesion to a plastic or to an endothelial layer. However, cellular motility was markedly elevated at pH 6.6 and this effect was sustained even when extracellular pH was switched back to pH 7.4. When analyzing the underlying mechanism, a prominent role of ROS in the induction of migration was observed. Signaling through the MAP kinases ERK1/2 and p38 as well as Src family kinases was not involved. Thus, cancer cells in an acidic microenvironment can acquire enhanced motili...Continue Reading

Citations

Feb 12, 2017·Seminars in Cancer Biology·Iryna KolosenkoAngelo De Milito
Dec 27, 2016·Journal of Cellular Physiology·Anja Paehler Vor der NolteUrsula Seidler
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu WuWen-Ning Wu
May 31, 2018·Stem Cells·Sergej SkvortsovAnna Dubrovska
Dec 25, 2019·Basic & Clinical Pharmacology & Toxicology·Óskar Ö HálfdánarsonHelga Zoega
Feb 8, 2019·Cancer Metastasis Reviews·Liu YangYin-Yuan Mo
Mar 2, 2019·Cancer Metastasis Reviews·Valéry L PayenPierre Sonveaux
Jan 5, 2019·Cancer Metastasis Reviews·Oliver Thews, Anne Riemann
Dec 22, 2020·The Journal of Physiology·Peter Vaupel, Gabriele Multhoff
Nov 3, 2020·Current Tissue Microenvironment Reports·LaDeidra Monet Roberts, Jennifer Munson
Jul 1, 2020·The International Journal of Biochemistry & Cell Biology·Tianyu ZhengBin Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.