Acinic cell carcinoma of the lacrimal gland

Archives of Ophthalmology
P S RosenbaumY Kress

Abstract

An 18-year-old woman underwent exenteration of the right orbit for tumor recurrence 3 years subsequent to external-beam irradiation for a lacrimal gland tumor diagnosed as an "adenocarcinoma." Light microscopy of the exenteration specimen revealed an acinic cell carcinoma of the lacrimal gland, with a predominant microcystic (latticelike) pattern of growth. Cytoplasmic vacuoles and the secretion within the microcysts stained positive with periodic acid-Schiff with and without alpha-amylase, alcian blue (at a pH of 2.5), mucicarmine, and colloidal iron with and without hyaluronidase. This histochemical staining for epithelial mucins supports the theory that the lacrimal gland, although serous in type, may also function as a modified mucus gland. There was cytoplasmic immunopositivity for keratin (CAM 5.2, KAE 1-3); immunostaining for vasoactive intestinal polypeptide was negative. Electron microscopy disclosed undifferentiated features of intercalated duct cells. We speculate that the lack of immunoreactivity for vasoactive intestinal polypeptide may be correlated with the predominantly undifferentiated intercalated duct cell features observed ultrastructurally.

Citations

Dec 18, 2010·Annals of Diagnostic Pathology·Lei HuoNour Sneige
Apr 5, 2012·Acta Ophthalmologica·Sarah Linéa von HolsteinSteffen Heegaard
Apr 6, 2005·Pathology, Research and Practice·Yoshitaka KurisuTsukasa Itabashi
Jun 13, 2015·Ophthalmic Plastic and Reconstructive Surgery·Asher NerenRoman Shinder
Jan 31, 2004·Ophthalmic Plastic and Reconstructive Surgery·Jerry A ShieldsRalph C Eagle
Jan 5, 2002·Ophthalmic Plastic and Reconstructive Surgery·J JangT C Spoor
Jan 18, 2019·Analytical Cellular Pathology (Amsterdam)·Sun Eui KimSang Soo Kim
Mar 9, 2018·International Ophthalmology Clinics·Alan D ProiaJulie A Woodward
Aug 6, 2021·Laryngo- rhino- otologie·Ulrich KisserAlexander Glien

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