Acne - a potential skin marker of internal disease

Clinics in Dermatology
Joseph L Pace

Abstract

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in adult women. Hyperandrogenism is the crux of the pathogenesis of both acne and hirsutism, the most frequent clinical presentations of the syndrome. The chronic anovulation that may occur, often but not always associated with enlarged cystic ovaries, has long been recognized as an important feature of PCOS. In recent years major changes have occurred with regard to PCOS: Although management of the common cutaneous manifestations, mainly acne, hirsutism, alopecia, and acanthosis nigricans, remains strictly within the realm of daily dermatologic practice, the pendulum is shifting toward greater awareness of the longer-term systemic implications of PCOS, with emphasis on the unique opportunity and privileged position of the dermatologist to diagnose this potentially serious problem at an early stage, when effective long-term treatment can be instituted. Patients need to be advised that PCOS cannot be cured but can be controlled. Management should involve a multidisciplinary team with emphasis on lifestyle change, insulin sensitizing agents, androgen blockers, and attention to specific cutaneous manifestations.

References

Dec 1, 1989·The British Journal of Dermatology·C B BunkerP M Dowd
Apr 16, 1988·Lancet·D W PolsonS Franks
May 1, 1996·Annals of Neurology·J I IsojärviV V Myllylä
Jul 7, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·D Lehucher-CeyracP Morel
Jan 5, 2002·The American Journal of Medicine·E Carmina, R A Lobo
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·R AzzizL R Boots
Feb 2, 2006·The Journal of Clinical Endocrinology and Metabolism·Catherine Marin DeUgarteRicardo Azziz
Jul 25, 2007·American Journal of Clinical Dermatology·Amy T Lee, Lee T Zane
Jun 25, 2008·Annals of the New York Academy of Sciences·Hala Tfayli, Silva Arslanian
Jun 6, 2009·Journal of Endocrinological Investigation·M WasniewskaF De Luca
Oct 29, 2010·Fertility and Sterility·Ricardo AzzizMark O Goodarzi
Jan 21, 2011·Fertility and Sterility·Robert A WildEnrico Carmina
Apr 28, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·T VergouC Antoniou
Oct 18, 2012·Seminars in Reproductive Medicine·Richard S Legro
Jan 29, 2013·Molecular and Cellular Endocrinology·Stephen Corbett, Laure Morin-Papunen
Mar 19, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·J S HongD H Suh
Jun 4, 2014·American Journal of Clinical Dermatology·Najwa Somani, Diane Turvy

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Citations

Jul 26, 2017·Radiology·Maxime FondinCatherine Adamsbaum
May 4, 2017·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·X RuanA O Mueck

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