Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Wolf-Ingo Worret, Joachim W Fluhr

Abstract

Benzoyl peroxide (BPO) was introduced in the treatment of acne in 1934. Despite the fact that only few randomized trials have been published, BPO is considered the standard in topical acne treatment. Anaerobic bacteria are reduced by oxidative mechanisms and the induction of resistant strains is reduced. Topical formulations are available at concentrations of 2.5, 5, 10 and 20 %. The effect is dose-dependent, but the irritation increases with higher concentrations. Usually 5 % BPO is sufficient to control acne grade I-II. Due to its strong oxidative potential, patients should be advised that BPO may bleach colored and dark clothing, bedding and even hair. BPO is safe for use in pregnant and lactating females because it is degraded to benzoic acid. It is a cost-effective treatment for acne grade I-II. Patients with papulopustular acne grade I-II, particularly with marked inflammation, show satisfactory improvement with topical antibiotic treatment. The following compounds are available and effective: erythromycin, clindamycin and tetracycline (the latter being less frequently used). A review in 1990 suggested that topical tetracycline was ineffective in the treatment of acne. Along with eliminating Propionibacterium acnes, the m...Continue Reading

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Citations

Dec 17, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H C Korting, C Schöllmann
Feb 23, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C Bayerl
Jan 1, 2009·Clinical, Cosmetic and Investigational Dermatology·Jonette Keri, Michael Shiman
Aug 5, 2014·Therapeutic Delivery·Varsha B PokharkarGanesh A Barhate
Jun 5, 2012·The Journal of Dermatological Treatment·Noor Hidayah Mohd Nor, Zoriah Aziz
Nov 21, 2012·Expert Opinion on Drug Safety·Shivani V TripathiSteven R Feldman
May 27, 2011·Cutaneous and Ocular Toxicology·Hamidreza Pazoki-ToroudiAlireza Firooz
Oct 16, 2013·Pediatric Annals·Wendy Kim, Anthony J Mancini
Mar 1, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A NastB Rzany
Nov 23, 2011·Clinical and Experimental Dermatology·K P WilhelmU Schwantes
Oct 4, 2018·Phytotherapy Research : PTR·Gabsik YangJoo Young Lee
Apr 30, 2020·Expert Opinion on Drug Safety·Agnieszka OtlewskaAleksandra Batycka-Baran
Sep 19, 2009·Expert Opinion on Pharmacotherapy·Matt SagranskySteven R Feldman
Nov 27, 2020·International Journal of Nanomedicine·Antonia MancusoDonatella Paolino
Jan 27, 2020·International Journal of Pharmaceutics·Christoph Brammann, Christel C Müller-Goymann
Feb 6, 2021·Journal of Shoulder and Elbow Surgery·Vendela M ScheerJohan H Scheer
May 13, 2018·Journal of the American Academy of Dermatology·Taylor EdwardsSteven R Feldman

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