Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles

The Journal of Investigative Dermatology
Dilip Y PaithankarR Rox Anderson

Abstract

The pathophysiology of acne vulgaris depends on active sebaceous glands, implying that selective destruction of sebaceous glands could be an effective treatment. We hypothesized that light-absorbing microparticles could be delivered into sebaceous glands, enabling local injury by optical pulses. A suspension of topically applied gold-coated silica microparticles exhibiting plasmon resonance with strong absorption at 800 nm was delivered into human pre-auricular and swine sebaceous glands in vivo, using mechanical vibration. After exposure to 10-50 J cm(-2), 30 milliseconds, 800 nm diode laser pulses, microscopy revealed preferential thermal injury to sebaceous follicles and glands, consistent with predictions from a computational model. Inflammation was mild; gold particles were not retained in swine skin 1 month after treatment, and uptake in other organs was negligible. Two independent prospective randomized controlled clinical trials were performed for treatment of moderate-to-severe facial acne, using unblinded and blinded assessments of disease severity. Each trial showed clinically and statistically significant improvement of inflammatory acne following three treatments given 1-2 weeks apart. In Trial 2, inflammatory lesi...Continue Reading

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Citations

Dec 9, 2015·Drug Delivery and Translational Research·Irit Allon, Elka Touitou
Jun 13, 2015·The Journal of Investigative Dermatology·Xiaolong Zhou, Mariya Miteva
Jun 13, 2015·The Journal of Investigative Dermatology·Mohammed AlsaidanKeyvan Nouri
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Methods Mentioned

BETA
surface plasmon resonance
biopsies

Clinical Trials Mentioned

NCT02219074

Software Mentioned

IntegReview

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