PMID: 15229041Jul 2, 2004Paper

ACOG Committee Opinion #296: first-trimester screening for fetal aneuploidy

Obstetrics and Gynecology

Abstract

First-trimester screening for chromosomal abnormalities offers potential advantages over second-trimester screening. Studies in the 1900s demonstrated an association between chromosomal abnormalities and the ultrasonographic finding of abnormally increased nuchal translucency (an echo-free area at the back of the fetal neck) between 10 and 14 weeks of gestation. First-trimester screening using nuchal translucency, free beta-hCG, and pregnancy-associated plasma protein-A has comparable detection rates and positive screening rates for Down syndrome as second-trimester screening using 4 serum markers (alpha-fetoprotein, beta-hCG, unconjugated estriol, and inhibin-A). Although first-trimester screening for Down syndrome and trisomy 18 is an option, it should be offered only if certain criteria can be met.

Citations

Feb 28, 2008·Clinical Obstetrics and Gynecology·Soha Said, Fergal D Malone
Jul 19, 2011·Journal of Vascular and Interventional Radiology : JVIR·Joseph CiacciMichael Bettmann
Jul 31, 2007·Fertility and Sterility·William H Parker
Oct 10, 2009·Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality·Joanne Weinschreider, Rita Dadiz
Aug 22, 2006·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Kimberly D GregoryStephen S Entman
Aug 24, 2006·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Drake E BellangerKay Solar
Mar 31, 2007·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Siobhan DolanKarla Damus
Nov 16, 2006·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hidehiko MiyakeToshiyuki Takeshita
Dec 27, 2005·Prenatal Diagnosis·Geralyn M Lambert-MesserlianMary E D'Alton
May 9, 2007·Journal of Clinical Ultrasound : JCU·Joseph R WaxJacquelyn Blackstone
Jul 3, 2007·Obstetrics and Gynecology·Robert H BallUNKNOWN First and Second Trimester Evaluation of Risk (FASTER) Research Consortium
Jan 6, 2006·Obstetrics and Gynecology·Jane Cleary-GoldmanJay Schulkin
Jun 4, 2005·Obstetrics and Gynecology·Federico PrefumoBaskaran Thilaganathan
Mar 6, 2007·Journal of Midwifery & Women's Health·Margaret L Holland, Eliza S Holland
Jun 18, 2005·Clinical Chemistry·Glenn E PalomakiJames E Haddow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Obstetrics and Gynecology
Lawrence PlattFirst Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group
The New England Journal of Medicine
Fergal D MaloneFirst- and Second-Trimester Evaluation of Risk (FASTER) Research Consortium
© 2022 Meta ULC. All rights reserved