ACOG Committee Opinion No. 771: Umbilical Cord Blood Banking

Obstetrics and Gynecology

Abstract

Since the first successful umbilical cord blood transplant in 1988, it has been estimated that more than 35,000 transplants have been performed in children and adults for the correction of inborn errors of metabolism, hematopoietic malignancies, and genetic disorders of the blood and immune system. Two types of banks have emerged for the collection and storage of umbilical cord blood: 1) public banks and 2) private banks. The benefits and limitations of public versus private umbilical cord blood banking should be reviewed with the patient because they serve different purposes. This patient discussion also should include the concept of autologous and allogeneic use of umbilical cord blood. Umbilical cord blood collected from a neonate cannot be used to treat a genetic disease or malignancy in that same individual (autologous transplant) because stored cord blood contains the same genetic variant or premalignant cells that led to the condition being treated. There is no current evidence to support the use of an autologous umbilical cord blood sample in regenerative medicine. Patients should be made aware of the quality control and regulatory organizations that provide oversight for the process of umbilical cord collection and sto...Continue Reading

References

May 1, 1997·Journal of Pediatric Hematology/oncology·F L Johnson
Nov 27, 2004·The New England Journal of Medicine·Mary J LaughlinMary M Horowitz
Nov 27, 2004·The New England Journal of Medicine·Vanderson RochaUNKNOWN Eurocord-Netcord Registry
Feb 16, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J J NietfeldMary M Horowitz
Nov 6, 2009·Obstetrics and Gynecology·Anjali J KaimalYvonne W Cheng
Jan 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael BooMartin Maiers
May 16, 2013·Blood·Karen K BallenHal E Broxmeyer
Jul 11, 2013·Nature Biotechnology·Sarah Webb
Nov 8, 2014·Stem Cells Translational Medicine·Javier MunozElizabeth J Shpall
Nov 1, 2017·Pediatrics·William T ShearerUNKNOWN SECTION ON ALLERGY AND IMMUNOLOGY

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Citations

Aug 7, 2021·Clinics in Perinatology·Ola Andersson, Judith S Mercer

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