Acoustic and mechanical characterization of 3D-printed scaffolds for tissue engineering applications

Biomedical Materials
Mitra AliabouzarKausik Sarkar

Abstract

The acoustic and mechanical properties of 3D-printed porous poly-(ethylene glycol)-diacrylate (PEGDA) hydrogel scaffolds were investigated using an ultrasound pulse echo technique on different scaffold microstructures (solid, hexagonal and square pores). Acoustic parameters such as speed of sound, acoustic impedance and attenuation coefficient as well as physical parameters such as the pore structure, effective density and elastic moduli were determined. The results show that microstructure (porosity and pore geometry) plays a crucial role in defining properties of 3D-printed scaffolds, achieving the highest attenuation for the scaffold with hexagonal pores and showing a decrease in sound speed and elastic moduli with increasing porosity. The properties were also found to be similar to those of soft tissues, making PEGDA scaffolds a suitable candidate for tissue engineering applications. To evaluate their cellular performance, adhesion and proliferation of human mesenchymal stem cells (hMSCs) in these scaffolds were investigated. The porous scaffolds performed better than the solid one, recording the highest cell attachment and growth for the scaffold with the square pores.

References

Jan 1, 1979·Tissue & Cell·P Gomez-Ramos, E L Rodriguez-Echandia
Sep 1, 1978·Medical Physics·E L MadsenR E Jutila
Nov 1, 1991·Physics in Medicine and Biology·M B Tavakoli, J A Evans
Apr 1, 1990·The Journal of the Acoustical Society of America·D H AgemuraD E Eyre
Jun 1, 1993·IEEE Transactions on Bio-medical Engineering·W Xu, J J Kaufman
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R StrelitzkiA J Clarke
Jul 1, 1997·Ultrasonic Imaging·S KrishnanM O'Donnell
Jul 4, 1998·Ultrasound in Medicine & Biology·E L MadsenF Dong
Sep 29, 2000·The Journal of the Acoustical Society of America·S ChaffaïP Laugier
Jul 25, 2003·Ultrasound in Medicine & Biology·J E BrowneP R Hoskins
Jun 1, 1958·American Journal of Physical Medicine·K T DUSSIKR S SEAR
Oct 14, 2003·Ultrasound in Medicine & Biology·Adrian F ProkopLawrence A Crum
Oct 20, 2004·Journal of Cellular and Molecular Medicine·D BakshR S Tuan
Oct 1, 1994·Physics in Medicine and Biology·A J ClarkeM A Smith
Dec 29, 2004·Biomaterials·Pamela HabibovicKlaas de Groot
Jul 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Celeste M NelsonChristopher S Chen
Mar 10, 2006·Annals of Biomedical Engineering·James J Norman, Tejal A Desai
Oct 9, 2007·Physics in Medicine and Biology·K ZellC Haisch
Mar 20, 2008·Journal of the Royal Society, Interface·Monika RumplerPeter Fratzl
Apr 23, 2008·Annals of Medicine·Sanna M PeltolaMinna Kellomäki
Jun 7, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Christian DemitriAlfonso Maffezzoli
Nov 14, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·B P Chan, K W Leong
Jul 1, 1999·Journal of Biomedical Optics·M ShopovaS Mueller
Jan 17, 2013·Acta Biomaterialia·Philipp M HungerUlrike G K Wegst
Feb 14, 2013·Annals of Biomedical Engineering·J KnychalaB G Sengers
Jan 1, 2012·International Journal of Biomedical Engineering and Technology·Sean S KohlesAsit K Saha
May 16, 2013·Tissue Engineering. Part B, Reviews·Qiu Li Loh, Cleo Choong
Jan 1, 2011·Journal of Functional Biomaterials·Silke WüstSandra Hofmann
Aug 2, 2014·Tissue Engineering. Part B, Reviews·Christopher M O'BrienLijie Grace Zhang
Jun 23, 2015·Advanced Healthcare Materials·Anh-Vu DoAliasger K Salem
Oct 1, 2015·Journal of Materials Science. Materials in Medicine·Roberto De SantisLuigi Ambrosio

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