Acoustic characterization of a new trisacryl contrast agent. Part I: In vitro study

Ultrasonics
Sonia LavisseNathalie Lassau

Abstract

The objective of the study was to acoustically characterize trisacryl polymeric microparticles (TMP), which are derived from biocompatible embolic agents. With significant acoustic properties, these polymeric particles could be potentially used as targeted ultrasound contrast agents, directed towards a specific site, with ligands conjugation on the polymeric network surface. In the in vitro study, a pulser/receiver (PRF of 1 kHz), associated to different transducers (5, 10 and 15 MHz), was used to measure the acoustic properties of the TMP inserted in a Couette flow device. Acoustic characterization according to TMP concentration (0.12-15.63 mg/ml), frequency (4.5-17 MHz, defined by each transducer bandwidth), ultrasound pressure (137-378 kPa) and exposure time (0-30 min) was conducted. Particle attenuation was also evaluated according to TMP concentration and emission frequency. Backscattering increased non linearly with concentration and maximum enhancement was of 16.4 dB+/-0.89 dB above 7.8 mg/ml. This parameter was found non-linear with increasing applied pressure and no harmonic oscillation could be noticed. Attenuation reached approximately 1.4 dB/cm at 15 MHz and for the 15.6 mg/ml suspension. The TMP have revealed in vi...Continue Reading

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Citations

Mar 31, 2012·Biomacromolecules·Torkel B BrismarGaio Paradossi
May 12, 2009·Ultrasound in Medicine & Biology·Dmitry GrishenkovGaio Paradossi
Feb 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lanxi ChenYan Li

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