Acoustic Cluster Therapy (ACT) - pre-clinical proof of principle for local drug delivery and enhanced uptake

Journal of Controlled Release : Official Journal of the Controlled Release Society
Annemieke van WamelCatharina de Lange Davies

Abstract

Proof of principle for local drug delivery with Acoustic Cluster Therapy (ACT) was demonstrated in a human prostate adenocarcinoma growing in athymic mice, using near infrared (NIR) dyes as model molecules. A dispersion of negatively charged microbubble/positively charged microdroplet clusters are injected i.v., activated within the target pathology by diagnostic ultrasound (US), undergo an ensuing liquid-to-gas phase shift and transiently deposit 20-30μm large bubbles in the microvasculature, occluding blood flow for ~5-10min. Further application of low frequency US induces biomechanical effects that increase the vascular permeability, leading to a locally enhanced extravasation of components from the vascular compartment (e.g., released or co-administered drugs). Results demonstrated deposition of activated bubbles in tumor vasculature. Following ACT treatment, a significant and tumor specific increase in the uptake of a co-administered macromolecular NIR dye was shown. In addition, ACT compound loaded with a lipophilic NIR dye to the microdroplet component was shown to facilitate local release and tumor specific uptake. Whereas the mechanisms behind the observed increased and tumor specific uptake are not fully elucidated, i...Continue Reading

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Citations

Jun 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Annemieke van WamelCatharina de Lange Davies
Jul 31, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Nov 13, 2018·Expert Opinion on Drug Delivery·Sofie SnipstadTwan Lammers
Jun 27, 2020·Advanced Drug Delivery Reviews·Tao SunSamir Mitragotri
Feb 2, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tormod K BjånesJan Schjøtt
Feb 8, 2021·Ultrasound in Medicine & Biology·Sofie SnipstadSigrid Berg
Jun 29, 2021·Advanced Drug Delivery Reviews·Sofie SnipstadCatharina de Lange Davies
Jul 19, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marieke OlsmanCatharina de Lange Davies
Jan 18, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Silke RooversIne Lentacker

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