Acoustic detection of intracranial aneurysms: a decision analysis

Acta neurochirurgica
A C van BruggenJ J Mooij

Abstract

We present a further evaluation of an improved recording method for the acoustic detection of intracranial aneurysms (ADA). A sensor was applied to the patient's eyes. Two measures were derived to summarize the power spectral density function of the sound frequencies that were obtained from each patient: the power median (PM), the median of the power spectral density function, and the mean difference error (MDE), a measure of the difference between the normalized, logarithmically transformed spectra of the patient and a template, the normal spectrum. The capability of these two measures (alone or combined) to discriminate between patients with and without an intracranial aneurysm was tested in a series of 89 patients harbouring a total of 109 aneurysms and 73 controls, using multiple logistic regression analysis. When PM and MDE were combined, the accuracy of the predictions amounted to 79%. Individualized threshold values of the likelihood ratio of harbouring an aneurysm, for ordering four-vessel angiography are suggested, depending on the prior probability of harbouring an aneurysm, the risks of unnecessary angiography and the risk of living with an undetected aneurysm. Our decision analysis suggests that using these recommen...Continue Reading

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Citations

Aug 24, 2012·Neurologia Medico-chirurgica·UNKNOWN Committee for Guidelines for Management of Aneurysmal Subarachnoid Hemorrhage, Japanese Society on Surgery for Cerebral Stro
Dec 22, 2001·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·J J Mooij

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