Acoustofluidics 8: applications of acoustophoresis in continuous flow microsystems

Lab on a Chip
Andreas LenshofThomas Laurell

Abstract

This acoustofluidics tutorial focuses on continuous flow-based half wavelength resonator systems operated in the transversal mode, where the direction of the primary acoustic force acts in plane with the microchip. The transversal actuation mode facilitates integration with up- and downstream microchannel networks as well as visual control of the acoustic focusing experiment. Applications of particle enrichment in an acoustic half wavelength resonator are discussed as well as clarification of the carrier fluid from undesired particles. Binary separation of particle/vesicle/cell mixtures into two subpopulations is outlined based on the different polarities of the acoustic contrast factor. Furthermore, continuous flow separation of different particle/cell types is described where both Free Flow Acoustophoresis (FFA) and binary acoustophoresis are utilized. By capitalizing on the laminar flow regime, acoustophoresis has proven especially successful in performing bead/cell translations between different buffer systems. Likewise, the ability to controllably translate particulate matter across streamlines has opened a route to valving of cells/particles without any moving parts, where event triggered cell sorting is becoming an incre...Continue Reading

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Citations

May 29, 2012·ACS Nano·Wei WangThomas E Mallouk
Mar 21, 2012·Lab on a Chip·Henrik Bruus
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyun DingTony Jun Huang
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Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyun DingTony Jun Huang
Jul 12, 2012·Lab on a Chip·Sz-Chin Steven LinTony Jun Huang
Aug 9, 2012·Lab on a Chip·Martin WiklundBjörn Onfelt
Oct 11, 2012·Lab on a Chip·Mikael Evander, Johan Nilsson
Jan 8, 2013·Lab on a Chip·Jeremy J Hawkes, Stefan Radel
Feb 7, 2013·Lab on a Chip·Peter Glynne-Jones, Martyn Hill
Jul 5, 2013·Lab on a Chip·Maïwenn Kersaudy-Kerhoas, Elodie Sollier
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Sep 7, 2014·Ultrasonics·Jeff E PrestJeremy J Hawkes
May 7, 2015·Lab on a Chip·Mikael EvanderThomas Laurell
May 7, 2015·Biomicrofluidics·I LeibacherP Koltay
Dec 7, 2013·Lab on a Chip·Ivo LeibacherJürg Dual
May 25, 2016·Ultrasonics Sonochemistry·Pablo JulianoKai Knoerzer

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