Acoustophoretic Mobility and Its Role in Optimizing Acoustofluidic Separations

Analytical Chemistry
Philip Stephen WilliamsM Hoyos

Abstract

In the separation sciences, sample species are separated according to their physicochemical properties, the nature of the selective field, and, if present, the properties of the medium in which they are dissolved or suspended. Separations may be carried out on a continuous basis in microfluidic devices or split-flow thin channel (SPLITT) devices by selectively transporting species in a direction transverse to the direction of flow of the suspending fluid. Separation is achieved in the so-called transport mode according to relative differences in mobility of the species under the influence of the applied field. Gravitational, centrifugal, thermal gradient, magnetic, electric, and dielectric fields may all be used for continuous SPLITT fractionation. We present here the theory for optimizing the operation of the relatively new technique of acoustic SPLITT fractionation for the continuous separation of non-Brownian materials. The theory is based on a quantitatively defined acoustophoretic mobility that is consistent with the generalized concept of mobility proposed by Giddings. Until now, acoustophoretic mobility has almost exclusively been used as a qualitative descriptor for velocity induced by an acoustic field. The quantitativ...Continue Reading

References

Sep 18, 1999·Analytical Chemistry·P S WilliamsJ J Chalmers
Jun 28, 2001·Journal of Colloid and Interface Science·Hiroyuki Ohshima
Jul 31, 2001·Analytical Chemistry·T Masudo, T Okada
Mar 28, 2003·Analytical Chemistry·P Stephen WilliamsMaciej Zborowski
Mar 17, 2004·Biosensors & Bioelectronics·Jeremy J HawkesMartin B McDonnell
Dec 14, 2004·Biotechnology and Bioengineering·Manoj KumarJoanne M Belovich
Oct 26, 2005·Biosensors & Bioelectronics·Stacey P MartinW Terence Coakley
Feb 28, 2007·Chemical Society Reviews·Thomas LaurellAndreas Nilsson
Jul 31, 2008·Ultrasonics·R J TownsendM B McDonnell
Aug 14, 2008·Analytical Chemistry·P Stephen WilliamsMaciej Zborowski
Sep 11, 2009·The Journal of the Acoustical Society of America·P Glynne-JonesP Baclet
Oct 6, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mauricio HoyosMarcela Camacho
Nov 6, 2009·Ultrasonics·P Glynne-JonesN R Harris
Feb 18, 2010·Lab on a Chip·Rune BarnkobHenrik Bruus
Mar 15, 2011·Journal of Magnetism and Magnetic Materials·Mauricio HoyosMaciej Zborowski
Mar 1, 2012·Lab on a Chip·Andreas LenshofThomas Laurell
Aug 18, 2012·Analytical Chemistry·Per AugustssonThomas Laurell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.