ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis

Autoimmunity Reviews
Xiwen DongPing Zhu

Abstract

The production of anti-citrullinated peptide antibodies (ACPAs) requires the participation of both innate immunity and adaptive immunity. On the one hand, activated innate immunity is able to produce citrullinated auto-antigens that fuel autoimmunity and provide an inflammatory environment that facilitates the breach of self-tolerance, proliferation of self-reactive T/B cells and the production of ACPAs. On the other hand, after their production by plasma B cells, ACPAs are also able to interact with innate immunity to exacerbate the manifestation and chronicity of rheumatoid arthritis (RA). This article discusses the roles of citrullinated peptides and ACPA played in innate immunity and autoimmunity. In addition, we emphasise the relationships between environmental factors and innate immunity, as well as the pathogenic function of ACPAs per se. In doing so, we hope to provide fundamental knowledge of RA pathogenesis and reveal potential therapeutic targets in RA treatment.

Citations

Dec 18, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yingjie ZhaoWei Wei
Jun 7, 2019·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Dec 18, 2020·Autoimmunity Reviews·Ze Xiu XiaoSong Guo Zheng
Jan 15, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Ruchi YadavBalázs Rada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.