Acquired angioedema induced by angiotensin-converting enzyme inhibitors - experience of a hospital-based allergy center

Experimental and Therapeutic Medicine
Polliana Mihaela LeruDaniel Boda

Abstract

Angiotensin-converting enzyme inhibitors (ACEIs) represent an important group of pharmacological compounds, largely prescribed for more than 30 years. They have been extensively evaluated in clinical trials, demonstrating significant reduction of morbidity and mortality of patients with cardiovascular diseases, mainly high blood pressure, myocardial infarction, heart failure and stroke. Besides their beneficial effects and a general good safety profile, it was proven that ACEIs might also induce adverse effects in some patients, most notably angioedema (AE) and chronic cough. The occurrence rate of adverse events induced by ACEIs is low, but the number of suffering patients is relatively high, since ACEIs is one of the most frequently prescribed medication worldwide. The aim of our study was to evaluate clinical pattern, risk factors and general management of ACEI-induced angioedema in a cohort of patients addressed for allergist evaluation in one university hospital in Romania, during a period of 32 months. It was found that ACEI-induced angioedema (ACEI-AE) represented more than half of the total number of patients addressed for angioedema without urticaria, with variable clinical and time-patterns. Most of the patients were ...Continue Reading

References

Dec 1, 1996·Australian and New Zealand Journal of Medicine·G M GabbK A Hutchinson
Dec 22, 1999·Immunopharmacology·A AgostoniJ Nussberger
Aug 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A Agostoni, M Cicardi
May 23, 2002·Cleveland Clinic Journal of Medicine·Mark E Dunlap, Ross C Peterson
Aug 23, 2002·The New England Journal of Medicine·Juerg NussbergerMarco Cicardi
Oct 16, 2004·Journal of Evaluation in Clinical Practice·Takeshi MorimotoDavid W Bates
Jan 5, 2006·Circulation·Qiuping GuVicki Burt
Oct 25, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Lorenza C ZingaleMarco Cicardi
Sep 8, 2007·Nature Reviews. Drug Discovery·Richard E T Smith, Mona Ashiya
May 3, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Aleena BanerjiCarlos A Camargo
Aug 8, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T HooverP Herscu
Jul 30, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Marco Cicardi, Andrea Zanichelli
Apr 24, 2012·The American Journal of Cardiology·Harikrishna MakaniSripal Bangalore
Mar 29, 2014·Allergy·M CicardiUNKNOWN HAWK under the patronage of EAACI (European Academy of Allergy and Clinical Immunology)
Apr 3, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Polliana Mihaela Leru
Nov 18, 2014·International Archives of Allergy and Immunology·Timothy J CraigIsabelle Boccon-Gibod
May 28, 2016·BMJ Case Reports·Troels Krogh NielsenEva Rye Rasmussen
Nov 6, 2018·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Polliana Mihaela LeruHoria Bumbea
Jan 27, 2019·Experimental and Therapeutic Medicine·Irena Nedelea, Diana Deleanu

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Allergy, Asthma & Immunology Research
Mario Sánchez-Borges, Luis A González-Aveledo
Advanced Emergency Nursing Journal
Josh Bankston, David Thomas House
Current Opinion in Allergy and Clinical Immunology
Paloma CampoCristobalina Mayorga
Australian and New Zealand Journal of Medicine
G M GabbK A Hutchinson
© 2022 Meta ULC. All rights reserved