Abstract
The incidence of renal cell carcinoma (RCC) is known to be higher in patients with end-stage renal disease, including those with acquired cystic kidney disease due to dialysis. Acquired cystic disease (ACD)-associated RCC was recently incorporated into the 2016 WHO Classification of Tumors of the Urinary System and Male Genital Tract as a distinct entity and is reportedly the most common RCC arising in end-stage renal disease. In this study, we sought to further describe clinicopathologic findings in a large series of ACD-RCC, emphasizing histologic features, immunophenotype, clinical outcome, and patterns of disease spread. We collected 40 previously unpublished cases of ACD-RCC with mean clinical follow-up of 27 months (median, 19 mo; range, 1 to 126 mo). Mean tumor size was 2.7 cm (median, 2.4 cm), and 32 tumors (80%) were confined to the kidney (pT stage less than pT3a). International Society of Urological Pathology grade was 3 in 37 cases (92.5%), grade 2 in 1 case (2.5%), and grade 4 in 2 cases (5%). Architectural variability among ACD-RCC was common, as 39 cases (98%) showed varying combinations of tubular, cystic, solid, and/or papillary growth. ACD-RCC frequently occurred in association with other renal tumor subtypes ...Continue Reading
References
Nov 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·I IshikawaS Suzuki
May 1, 1986·Cancer·P N BretanR D Williams
Jul 1, 1973·Kidney International·W R Salyer, D Keren
Oct 1, 1994·Urology·J C PopeR F Bluth
Feb 1, 1993·Histopathology·I Ishikawa, G Kovacs
May 25, 2002·Kidney International·Mark D DentonNina Tolkoff-Rubin
Aug 28, 2002·Human Pathology·Wah CheukJohn K C Chan
Feb 4, 2003·Archives of Pathology & Laboratory Medicine·Nathalie C Rioux-Leclercq, Jonathan I Epstein
Mar 16, 2005·The American Journal of Surgical Pathology·Norbert SuleLuan D Truong
Jan 26, 2006·The American Journal of Surgical Pathology·Satish K TickooMahul B Amin
Apr 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paolo Cossu-RoccaLiang Cheng
Sep 27, 2007·The American Journal of Surgical Pathology·Maria J MerinoWilliam Marston Linehan
May 21, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Keisuke NishiharaHisao Ito
Sep 17, 2008·Virchows Archiv : an International Journal of Pathology·Ondrej HesMichal Michal
Sep 15, 2009·BJU International·Mohammed A A M NouhYoshiyuki Kakehi
Oct 19, 2010·Annals of Diagnostic Pathology·Naoto KurodaChin-Chen Pan
Oct 27, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Goh, A Vathsala
Dec 20, 2011·Medical Molecular Morphology·Naoto KurodaGang-Hong Lee
Sep 13, 2013·The American Journal of Surgical Pathology·John R SrigleyUNKNOWN ISUP Renal Tumor Panel
Apr 30, 2014·Human Pathology·Mojgan HosseiniAnthony Chang
Feb 24, 2016·The American Journal of Surgical Pathology·Kiril TrpkovAnthony J Gill
Citations
Jun 10, 2020·International Journal of Surgical Pathology·Magdalena ChrabańskaDrozdzowska Bogna
Apr 10, 2020·The American Journal of Surgical Pathology·Fumiyoshi KojimaMahul B Amin
Nov 26, 2019·Archives of Pathology & Laboratory Medicine·Alexander S TaylorRohit Mehra
Aug 30, 2020·Cancer Science·Hiroki IshiharaToshikazu Ushijima
Aug 21, 2018·World Journal of Urology·Anne Y Warren, David Harrison
Jul 1, 2020·The American Journal of Surgical Pathology·Abhishek ShahAnupma Nayak
Jan 31, 2021·Annals of Diagnostic Pathology·Fumiyoshi KojimaOndrej Hes
Feb 10, 2021·The American Journal of Surgical Pathology·Sean R WilliamsonDavid J Grignon
Mar 6, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kiril TrpkovAnthony J Gill
Aug 26, 2020·Archives of Medical Research·Maria S Tretiakova
May 6, 2021·Pathology·Tsunenori KondoToyonori Tsuzuki
Jun 10, 2021·Medicine·Yue SongLianhui Fan
Jun 13, 2021·Urologic Oncology·Alexander S Taylor, Stephanie L Skala