Acquired decrease of the C3b/C4b receptor (CR1, CD35) and increased C4d deposits on erythrocytes from ICU COVID-19 patients.

Immunobiology
Aymric KisserliJacques Hm Cohen

Abstract

In order to study the mechanisms of COVID-19 damage following the complement activation phase occurring during the innate immune response to SARS-CoV-2, CR1 (the regulating complement activation factor, CD35, the C3b/C4b receptor), C4d deposits on Erythrocytes (E), and the products of complement activation C3b/C3bi, were assessed in 52 COVID-19 patients undergoing O2 therapy or assisted ventilation in ICU units in Rheims France. An acquired decrease of CR1 density on E from COVID-19 patients was observed (Mean = 418, SD = 162, N = 52) versus healthy individuals (Mean = 592, SD = 287, N = 400), Student's t-test p < 10-6, particularly among fatal cases, and in parallel with several parameters of clinical severity. Large deposits of C4d on E in patients were well above values observed in normal individuals, mostly without concomitant C3 deposits, in more than 80% of the patients. This finding is reminiscent of the increased C4d deposits on E previously observed to correlate with sub endothelial pericapillary deposits in organ transplant rejection, and with clinical SLE flares. Conversely, significant C3 deposits on E were only observed among ¼ of the patients. The decrease of CR1/E density, deposits of C4 fragments on E and previo...Continue Reading

References

Jan 1, 1979·Journal of Immunological Methods·W H Anderson, R M Stroud
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D T Fearon
Nov 1, 1978·The Journal of Clinical Investigation·G D RossT Hoffman
Dec 1, 1991·Clinical and Experimental Immunology·H E FeuchtE Albert
May 1, 1991·Clinical and Experimental Immunology·C M Giles, T Robson
Jan 1, 1986·Annual Review of Immunology·H J Müller-Eberhard
Sep 24, 1983·Lancet·J R Le GallA Alperovitch
Nov 1, 1981·Bioscience Reports·R D SchreiberH J Müller-Eberhard
Oct 1, 1984·The Journal of Clinical Investigation·F J WaxmanJ M Taguiam
Feb 1, 1983·The Journal of Clinical Investigation·J B CornacoffF J Waxman
May 1, 1981·The Journal of Experimental Medicine·K Iida, V Nussenzweig
Mar 1, 1994·The Journal of Experimental Medicine·M PascualJ A Schifferli
Nov 5, 1997·Immunity·L B KlicksteinA Nicholson-Weller
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S OudinJ H Cohen
Dec 20, 2000·The Journal of Experimental Medicine·I GhiranA Nicholson-Weller
Apr 5, 2001·The New England Journal of Medicine·M J Walport
Apr 12, 2001·The New England Journal of Medicine·M J Walport
Oct 9, 2002·Journal of Molecular Biology·Jean M H van den ElsenDavid E Isenman
Sep 23, 2003·Current Opinion in Immunology·Steven H SacksWuding Zhou
Aug 21, 2004·The Journal of Infectious Diseases·John N WaitumbiJosé A Stoute
Nov 6, 2004·Arthritis and Rheumatism·Susan ManziJoseph M Ahearn
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura A KerepesiDavid Abraham
Nov 9, 2007·Nature Biotechnology·Daniel Ricklin, John D Lambris
Dec 22, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Angali GolocheikineThalachallour Mohanakumar
Jul 28, 2011·Cellular Microbiology·José A Stoute
Aug 4, 2011·Seminars in Immunopathology·Katerina OikonomopoulouJohn D Lambris
Mar 17, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F HaidarJ H M Cohen
Feb 7, 2014·Annual Review of Immunology·V Michael Holers
Feb 11, 2015·Neurobiology of Aging·Rachid MahmoudiJacques H Cohen
Jun 18, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Jul 16, 2015·Frontiers in Immunology·Lubna KouserUday Kishore

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