PMID: 9439987Jan 1, 1997Paper

Acquired dyschromatopsia in combined exposure to solvents and alcohol

International Archives of Occupational and Environmental Health
E ValicC Wolf

Abstract

Does occupational exposure to solvents in combination with alcohol intake give rise to acquired color vision defects? A total of 138 individuals exposed to solvents (toluene, xylene, trichloroethylene, tetrachloroethylene) were examined using Lanthony's D-15 test and compared with 100 nonexposed controls. The extent of color vision loss was quantitatively assessed based on Bowman's color confusion index (CCI). A cumulative exposure index was calculated from the hours of exposure per day and the years of exposure. In 30 persons who were exposed to trichloroethylene and tetrachloroethylene, urinary trichloroacetic acid was assessed as a parameter of exposure. Alcohol intake was calculated as based on interviews of patients in grams of ethyl alcohol per week. Individuals who consumed more than 250 g alcohol/week and were simultaneously exposed to solvents showed a significantly elevated CCI (P = 0.0044). No significant correlation emerged between trichloroacetic acid excretion in the urine or the cumulative exposure index and the CCI. The combination of alcohol intake and occupational exposure to solvents discloses the risk of acquired subclinical color vision defects.

Citations

Aug 4, 2004·Neurotoxicology·Galina V ParameiAndreas Seeber
Aug 6, 2003·Neurotoxicology·Fabriziomaria Gobba, Alessandro Cavalleri
Nov 17, 2001·Neurotoxicology and Teratology·D CampagnaG Huel
Dec 13, 2006·Archives of Environmental & Occupational Health·Stephanie I DavisCaroline Cusack
Jun 30, 2006·Neurotoxicology·Eun-Hee LeeDo Myung Paek
Nov 15, 2003·Environmental Research·John S ReifW Kent Anger
May 31, 2001·Journal of Occupational and Environmental Medicine·G TriebigM C Dietz
Dec 8, 2004·Toxicological Reviews·Richard B LomaxMaureen Meldrum

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