Acquired factor V deficiency: a rare bleeding disorder with variable clinical presentations

La Revue de médecine interne
M AlcantaraY Dargaud

Abstract

Acquired anti-factor V (FV) antibodies are uncommon and the majority of reported cases are idiopathic or associated with pregnancy, malignancy, autoimmune diseases or the use of bovine thrombin preparations. Clinical presentation is highly variable, ranging from asymptomatic to life-threatening bleeding and the optimal treatment is not clearly established. We here report two patients with different clinical presentations. The first patient presented with an acute severe rectal bleeding related to acquired FV deficiency and recurrent colon cancer while the second patient was asymptomatic with a FV inhibitor detected during a routine blood testing. We discuss treatment modalities that are not consensual.

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Citations

Jan 21, 2021·British Journal of Haematology·Tiphaine GoulenokUNKNOWN RAVI study group
Feb 1, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·F Pineau-VincentK Laribi

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