Acquired factor VIII inhibitor treated with cyclophosphamide, vincristine, and prednisone

American Journal of Hematology
Eric C-Y LianZoneddy Ruiz-Dayao

Abstract

Life-threatening bleeding can occur in non-hemophiliacs with factor VIII inhibitor and is difficult to control. Various methods have been used to suppress the inhibitor. Since 1993 we treated 6 non-hemophilic patients with factor VIII inhibitor with cyclophosphamide, vincristine, and prednisone (CVP) every 3-4 weeks. Five had complete response with disappearance of factor VIII inhibitor and normalization of factor VIII after 1 to 7 cycles of CVP. One patient did not respond after 4 cycles of CVP; mitoxantrone was added to additional two cycles of CVP, and the inhibitor disappeared.

References

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Citations

Jun 10, 2010·BMC Research Notes·Peter CollinsHervé Lévesque
Apr 27, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Galila Zaher, Soheir Adam
Feb 27, 2014·Journal of the American Veterinary Medical Association·Laramie S Winfield, Marjory B Brooks
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Jul 31, 2013·British Journal of Haematology·Peter W CollinsUNKNOWN United Kingdom Haemophilia Centre Doctors' Organization
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Oct 10, 2009·British Journal of Haematology·Peter W Collins, Charles L Percy
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Feb 11, 2012·Journal of Thrombosis and Haemostasis : JTH·P KnoeblUNKNOWN EACH2 Registry Contributors

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