Acquired factor VIII inhibitor with squamous cell cancer of the epiglottis

Archives of Otolaryngology--head & Neck Surgery
K A ShastriJ G Haar

Abstract

A 73-year-old woman developed an acquired factor VIII inhibitor in association with squamous cell carcinoma of the epiglottis. The inhibitor was an IgG antibody that reacted with factor VIII in vitro and in vivo. Intravenous gamma-globulin therapy was successful in reducing the inhibitor so that curative surgery could be undertaken. With surgical resection of the tumor the inhibitor did not recur. The relevance of this type of coagulation disorder to the surgical management of the patient's head and neck cancer is discussed.

Citations

Nov 27, 1998·The American Journal of Medicine·P BossiR Zittoun
Sep 30, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·M NapolitanoC M Kessler

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