Acquired free protein S deficiency associated with multiple myeloma: a case report

American Journal of Hematology
S R DeitcherS A Limentani

Abstract

Investigation of recurrent venous thromboembolic events in a 46-year-old man with progressive IgG kappa (total serum IgG, 74.3 mg/ml) multiple myeloma revealed profound reductions in free protein S (PS) antigen (<0.l U/ml) and PS activity (0.33 U/ml). Total PS antigen, protein C, antithrombin III, and C4b-binding protein levels were within normal limits. The patient had no family history suggestive of a congenital PS deficiency and no history of thrombosis predating the diagnosis of his plasma cell dyscrasia. Patient IgG was isolated from serum using a protein A-sepharose affinity column and characterized. PS-dependent clotting assays (Staclot Protein S, Diagnostica Stago, Asnieres sur-Seine, France) performed on normal pooled plasma mixed with dilutions of patient IgG (0.0-33.0 mg/ml) revealed a dose-dependent neutralization of PS activity by 43%. Total and free PS antigen levels were measured using Laurell rocket electroimmunodiffusion (Assera-Plate Protein S, Diagnostica Stago), which revealed a similar dose-dependent reduction in free PS antigen but preserved normal total PS antigen. Free PS antigen was reduced by 77% to 0.23 U/ml using an IgG concentration (16.5 mg/ml) less than one-fourth of that of the patient at time of...Continue Reading

References

May 15, 1979·FEBS Letters·J Stenflo, M Jönsson
Jan 1, 1985·Haemostasis·R M Bertina
May 1, 1987·Annals of Internal Medicine·L EngesserR M Bertina
Jul 1, 1987·Annals of Internal Medicine·S Vigano-D'AngeloP C Comp
May 15, 1986·Thrombosis Research·A GruberG Sas
Apr 1, 1984·Seminars in Thrombosis and Hemostasis·F J Walker
Dec 1, 1984·The Journal of Clinical Investigation·P C CompC T Esmon
Jun 17, 1993·The New England Journal of Medicine·A D'AngeloS Viganò D'Angelo

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Citations

Jan 1, 2009·Journal of Cancer Epidemiology·Isaac E HallCary P Gross
Jul 20, 2011·Leukemia & Lymphoma·Klaus LechnerIngrid Pabinger
May 28, 2014·Thrombosis Research·Domenico RibattiAngelo Vacca
Dec 27, 2011·Thrombosis Research·F Elice, F Rodeghiero
Nov 23, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Maria De BonisFelice Petraglia
May 3, 2001·Blood Reviews·D MateiV J Marder
Nov 25, 2003·American Journal of Hematology·Münci YağciRauf Haznedar
Sep 14, 2006·Rheumatology International·Seong Ryul KwonWon Park
Jul 15, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·P PottierB Planchon
Feb 13, 2009·British Journal of Haematology·Charles Eby
Apr 9, 2019·Expert Review of Hematology·Despina FotiouEvangelos Terpos
Sep 10, 2011·Journal of Thrombosis and Thrombolysis·Yonal IpekSargin Deniz
Nov 21, 2007·Hematology·Charles S Eby
Aug 11, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S GuermaziK Dellagi
Mar 7, 2007·Expert Review of Anticancer Therapy·Maurizio ZangariGuido Tricot
Mar 10, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T E ClarkL J Lindsey
Jan 17, 2020·Cancers·Despina FotiouEvangelos Terpos

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