Acquired hemophilia A: A rare cause of gross hematuria

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
Gregory W HosierGregory G Bailly

Abstract

Acquired hemophilia A is a rare condition caused by spontaneous development of factor VIII inhibitor. This condition most commonly presents with multiple hemorrhagic symptoms and isolated hematuria is exceedingly rare. Early diagnosis is important, as this condition carries a high mortality rate (13-22%). We present a case of an 82-year-old man with isolated hematuria caused by a factor VIII inhibitor who was successfully treated with recombinant activated factor VII concentrate, as well as prednisone and cyclophosphamide.

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