Acquired hemophilia with thrombosis in a cancer patient: an unusual presentation

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Senem MaralImdat Dilek

Abstract

: Acquired hemophilia A (AHA) which presents with spontaneous severe intramuscular, mucosal and/or subcutaneous bleeding is a rare bleeding disorder. Even 50% of AHA patients are defined as idiopathic; 10% of cases are related with malignancy. Here, we present a case of AHA in a 43-year-old lady who was diagnosed with malignancy and venous thromboembolism on vena cava 2 years ago. To the best of our knowledge, this is the first report in literature presented with both acquired hemophilia and thrombosis associated with malignancy. A routine workup for malignancy like solid tumors, lymphoproliferative, or myeloproliferative diseases should be performed and followed up for a long time despite clinical improvement for individuals presented with AHA. Moreover, because of warfarin treatment, the diagnosis may be difficult and delayed. Clinicans should rule out AHA in patients who are on warfarin treatment and have abnormal coagulation tests.

References

May 29, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Massimo FranchiniGiuseppe Lippi
Aug 1, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Rhonda L BittingJeffrey Kohlwes
Dec 1, 2010·Autoimmunity Reviews·Shrimati ShettyKanjaksha Ghosh
Feb 11, 2012·Journal of Thrombosis and Haemostasis : JTH·P KnoeblUNKNOWN EACH2 Registry Contributors
Jun 15, 2012·Thrombosis Research·Brandi N Reeves, Nigel S Key
Apr 12, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Y BorgUNKNOWN SACHA Study Group

❮ Previous
Next ❯

Citations

Jan 16, 2020·International Journal of Hematology·Yoshiyuki OgawaHiroshi Handa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica
Francesco CelestinoSavino Mauro Di Stasi
Folia clínica internacional
M DJALDETTIA DEVRIES
© 2022 Meta ULC. All rights reserved