Acquired hypoprothrombinemia: effects of danazol treatment

American Journal of Hematology
S WilliamsH R Gralnick

Abstract

The lupus anticoagulant may be accompanied by an acquired factor II deficiency and bleeding. We report on a patient with a lupus anticoagulant and factor II (Fll) deficiency responsive to Danazol. Acquired hypoprothrombinemia (FII) with the lupus anticoagulant (LA) may be accompanied by a hemorrhagic diathesis. A 64-year-old male with discoid lupus erythematosis bled after an intestinal polypectomy. His FII level was 18%, and his FII antigen level was 20%. Danazol (D) (600 mg per day) administration was associated with a rise in FII activity and antigen to 50% within 10 days. The patient underwent abdominal surgery. We studied the effect(s) of D on the FII level and on other coagulation factors in this patient. The patient's plasma FII antigen had a single precipitin arc compared to the two peaks of normal plasma on counterimmunoelectrophoresis with Ca++. The samples pre- and during D therapy had the same positively charged arc as normal samples, although they were quantitatively different. Neuraminidase treatment demonstrated a decrease in the positively charged migration of normal and the patient's FII antigen. Affinity chromatography of normal and patient plasma on a Sepharose protein A column revealed FII antigen present in...Continue Reading

References

Nov 1, 1979·The Journal of Clinical Endocrinology and Metabolism·C B Laurell, G Rannevik
Jul 1, 1978·Acta paediatrica Scandinavica·K B LillquistM Krogh-Jensen
Aug 1, 1991·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A K al-MomenD Ajarim
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
Aug 1, 1971·British Journal of Haematology·K W DensonR Biggs

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Citations

Dec 3, 2005·Hematology·Massimo Franchini, Dino Veneri
Aug 27, 1998·Journal of Medical Genetics·H V Toriello
Sep 20, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·R D Paschal, A T Neff

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