Acquired ichthyosis associated with chronic graft-versus-host disease following allogeneic peripheral blood stem cell transplantation in a patient with chronic myelogenous leukemia

Bone Marrow Transplantation
I DilekH Akan

Abstract

Acquired ichthyosis (AI) has rarely been described following bone marrow transplantation (BMT). We report a 29-year-old male, who underwent allogeneic peripheral blood stem cell transplantation (alloPBSCT) for chronic myelogenous leukemia, and who developed AI associated with chronic graft-versus-host disease (cGVHD). Both of these disorders were treated successfully with cyclosporin A. We conclude that AI may be related to an autoimmune process on the basis of cGVHD, and dermathopathologic evaluation must be performed in patients with skin changes suggesting AI following allogeneic bone marrow transplantation.

Citations

Dec 6, 2001·The Pediatric Infectious Disease Journal·J TolarC L Moertel
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Mar 26, 2003·Histopathology·M R Canninga-van DijkJ G van den Tweel
Oct 3, 2006·Journal of the American Academy of Dermatology·Nisha PatelMatthew J Zirwas

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