Acquired intestinal aganglionosis after a lytic infection with varicella-zoster virus

Journal of Pediatric Surgery
Stefan Holland-CunzKarl-Herbert Schäfer

Abstract

In this report, we present the first case of an immunologically impaired child surviving a lytic varicella-zoster virus infection affecting the enteric nervous system. In histological findings, myenteric and submucous enteric ganglia were nearly completely absent owing to virus infection. A 3-year-old girl with acute lymphoblastic leukemia and generalized varicella-zoster infection developed an ileus. She underwent multiple laparotomies in which histological sections of the entire small intestine could be obtained. The histological evaluation of these samples showed a generalized aganglionosis with inflammatory residuals. A more detailed immunohistochemical analysis using neuronal (PGP, enolase), glial (S100), and lymphocytic (LCA) antibodies demonstrated a nearly complete neuronal loss. To our knowledge, this is the first case of a secondary intestinal aganglionosis after varicella-zoster virus infection.

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Citations

Jun 24, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Isabella BarajonCristiano Rumio
Sep 13, 2012·World Journal of Gastroenterology : WJG·Eon Chul HanKyu Joo Park
Dec 13, 2006·Journal of Pediatric Surgery·Tomoaki TaguchiJunko Akiyoshi
Mar 22, 2016·Developmental Biology·Robert O Heuckeroth, Karl-Herbert Schäfer
Apr 3, 2016·The Journal of Infectious Diseases·Anne Gershon, Michael Gershon
Jul 21, 2016·Nature Reviews. Gastroenterology & Hepatology·Meenakshi Rao, Michael D Gershon
Nov 22, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Meng JiangShao-Tao Tang
Jan 25, 2020·Medicine·Zhi-Ping PanJun-Hui Cui
Apr 21, 2017·Virchows Archiv : an International Journal of Pathology·Koichiro YoshimaruYoshinao Oda
Jul 22, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Francisco Javier Carod-Artal
Mar 8, 2019·World Journal of Gastrointestinal Surgery·Allan Mf KwokKimberly Hart
Jan 28, 2021·Clinical Journal of Gastroenterology·Alice LeeJames Tow-Hing Lim
Jan 31, 2021·Nature Reviews. Gastroenterology & Hepatology·Beate NieslerKarl-Herbert Schäfer
Dec 1, 2020·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Aya YamagishiHiroshi Yoshida

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