Acquired Isolated FVII Deficiency: An Underestimated and Potentially Important Laboratory Finding

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
A GirolamiAnna Maria Lombardi

Abstract

To investigate all cases of isolated factor VII (FVII) deficiency as gathered from personal files or by a PubMed search. Personal files dealing with patients studied in Padua during the years 1970 to 2010 were reevaluated. The PubMed search was time unlimited and was carried on 2 occasions during 2014. Cross-checking of the references, listed in every article, was also carried out to avoid omissions. Inclusion criteria were isolated FVII defect of less than 40% of normal, negative coagulation pattern in the family, normal level of other vitamin K-dependent clotting factors, and normalization of the clotting factor after the therapeutic procedures, unless the patient died. Twenty-nine patients met the inclusion criteria (18 male and 9 female, in 2 cases gender was unreported). This number included 1 personal case. Mean age was 37.9 (range 3-80). Underlying diseases were the following: neoplasia, infections, polytrauma, penicillin administration, nephrotic syndrome Wiskott Aldrich syndrome, and left heart failure (1 case, each); 2 patients had no underlying disease. Bleeding was variable but usually mild. There were 11 fatalities. Isolated FVII deficiency is a rare defect, which appears to be a finding associated with several mor...Continue Reading

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Citations

Oct 5, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Pierre-Olivier SevenetFrancois Depasse
May 31, 2019·Scottish Medical Journal·Mehmood Hussain ZaidiMohammed Khan
Sep 10, 2019·Journal of Investigative Medicine High Impact Case Reports·Leila MoosaviEverardo Cobos
Jul 14, 2021·Seminars in Thrombosis and Hemostasis·Massimo FranchiniGiuseppe De Donno
Aug 15, 2021·Hematology/oncology Clinics of North America·Glaivy Batsuli, Peter Kouides

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