Abstract
To investigate all cases of isolated factor VII (FVII) deficiency as gathered from personal files or by a PubMed search. Personal files dealing with patients studied in Padua during the years 1970 to 2010 were reevaluated. The PubMed search was time unlimited and was carried on 2 occasions during 2014. Cross-checking of the references, listed in every article, was also carried out to avoid omissions. Inclusion criteria were isolated FVII defect of less than 40% of normal, negative coagulation pattern in the family, normal level of other vitamin K-dependent clotting factors, and normalization of the clotting factor after the therapeutic procedures, unless the patient died. Twenty-nine patients met the inclusion criteria (18 male and 9 female, in 2 cases gender was unreported). This number included 1 personal case. Mean age was 37.9 (range 3-80). Underlying diseases were the following: neoplasia, infections, polytrauma, penicillin administration, nephrotic syndrome Wiskott Aldrich syndrome, and left heart failure (1 case, each); 2 patients had no underlying disease. Bleeding was variable but usually mild. There were 11 fatalities. Isolated FVII deficiency is a rare defect, which appears to be a finding associated with several mor...Continue Reading
References
Dec 4, 1976·British Medical Journal·O EpsteinS Ardeman
Mar 1, 1990·The Annals of Thoracic Surgery·U BortolottiV Gallucci
Mar 1, 1989·British Journal of Haematology·D WeisdorfD S Fair
Dec 1, 1981·American Journal of Hematology·P R GreippE J Bowie
Apr 2, 1981·The New England Journal of Medicine·B FurieB C Furie
Jun 1, 1980·The American Journal of Medicine·E CampbellS Hampton
Oct 1, 1994·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·E de RaucourtA M Fischer
Jun 1, 1996·Histopathology·L Berrutti, J S Silverman
Mar 1, 1997·Haemostasis·C BironJ F Schved
Aug 12, 1999·British Journal of Haematology·B WhiteO P Smith
Sep 6, 2000·British Journal of Haematology·A D MumfordM Laffan
Mar 10, 2001·Blood·E B ChoufaniD C Seldin
Mar 29, 2002·Bone Marrow Transplantation·A A ToorN S Key
Aug 16, 2002·British Journal of Haematology·David J Perry
Feb 1, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·C AguilarP Hernández
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Charles G MullighanJohn V Lloyd
Oct 27, 2004·Transfusion·Weei-Yuarn HuangBeth H Shaz
Aug 16, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·E MeaudreB Palmier
Apr 1, 2008·Vitamins and Hormones·A GirolamiS Vettore
Jan 13, 2009·Pediatric Blood & Cancer·Jeremy Granger, Vinod K Gidvani
Dec 22, 2010·The Annals of Thoracic Surgery·Saulat Hasnain FatimiSarah K Kiani
Feb 26, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·G LeeAra D Metjian
Oct 8, 2013·Semergen·L Vico Besó, E Zúñiga Cedó
Jul 6, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Soumaya AnounAsmaa Quessar
Citations
Oct 5, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Pierre-Olivier SevenetFrancois Depasse
May 31, 2019·Scottish Medical Journal·Mehmood Hussain ZaidiMohammed Khan
Sep 10, 2019·Journal of Investigative Medicine High Impact Case Reports·Leila MoosaviEverardo Cobos
Nov 16, 2019·Signal Transduction and Targeted Therapy·Congran Li, Xuefu You
Aug 11, 2019·Cell Research·Jinwu ChenXu Song
Feb 6, 2021·BMJ Case Reports·Islam Tarek ElkhatebYssra Soliman
Nov 8, 2020·Signal Transduction and Targeted Therapy·Congran Li, Xuefu You
Jul 14, 2021·Seminars in Thrombosis and Hemostasis·Massimo FranchiniGiuseppe De Donno
Aug 15, 2021·Hematology/oncology Clinics of North America·Glaivy Batsuli, Peter Kouides