Acquired lipodystrophy associated with immune checkpoint inhibitors.

Melanoma Research
Subashini S GnanendranAndrew Miller

Abstract

Immune checkpoint inhibitors have become the mainstay of treatment for metastatic melanoma. This article presents a new case of acquired generalised lipodystrophy (AGL) during anti-programmed cell death-1 (anti-PD-1) therapy and a systematic review of the literature with an aim to further understand the pathogenesis. A comprehensive search was conducted using PubMed, Embase, MEDLINE and Cochrane Central databases. We identified four cases of lipodystrophy associated with anti-PD-1 immunotherapy, including our own. Of these, three were associated with nivolumab, and one with pembrolizumab. Body composition changes occurred at a median of 7 months after anti-PD-1 initiation. All cases reported AGL, with subcutaneous fat loss affecting majority of the body. There were three reported cases of insulin resistance associated with AGL. AGL should be a recognised adverse event associated with anti-PD-1 therapy.

References

May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C WeyerP A Tataranni
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Wasim A HaqueAbhimanyu Garg
Mar 19, 2004·The New England Journal of Medicine·Abhimanyu Garg
Mar 15, 2006·Current Opinion in Lipidology·Vinaya Simha, Abhimanyu Garg
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Apr 10, 2014·Nature Biotechnology·Gunjan Sinha
Oct 7, 2016·The Journal of Clinical Endocrinology and Metabolism·Rebecca J BrownTohru Yorifuji
Nov 9, 2016·Endocrinology and Metabolism Clinics of North America·Iram Hussain, Abhimanyu Garg
Oct 27, 2017·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Elaine ChiquettePraveen Dhankhar
Mar 20, 2018·Current Opinion in Immunology·Yann-Alexandre VanoCatherine Sautès-Fridman
Apr 29, 2018·Journal of Endocrinological Investigation·D Araújo-Vilar, F Santini
Jun 9, 2018·PloS One·Josivan Gomes LimaSelma Maria B Jeronimo
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Ragini R KudchadkarAlexander C J van Akkooi
Dec 14, 2018·Experimental & Molecular Medicine·Pramod DarvinEyad Elkord
Feb 20, 2019·The Journal of Clinical Endocrinology and Metabolism·Camila Kruschewsky FalcaoMilena Gurgel Teles
May 7, 2019·International Journal of Molecular Sciences·Hung-Chih LaiChung-Kuan Wu
May 12, 2019·The British Journal of Dermatology·N HaddadUNKNOWN PATIO group
Aug 23, 2019·Diabetes Care·Alexandre JehlEmmanuel Disse

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Citations

Mar 21, 2020·Current Treatment Options in Oncology·Subashini Sharon GnanendranAndrew Charles Miller

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