Acquired lymphedema: an urgent need for adequate animal models

Cancer Research
Catarina Hadamitzky, R Pabst

Abstract

In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications.

References

Apr 1, 1990·Plastic and Reconstructive Surgery·M A KanterW Kaplan
Oct 31, 1998·Vascular Medicine·A Szuba, S G Rockson
Oct 25, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrzej SzubaStanley G Rockson
Jan 25, 2003·Annals of the New York Academy of Sciences·Stanley G Rockson
Dec 31, 2004·Lymphatic Research and Biology·William S ShinStanley G Rockson
Jun 30, 2005·Palliative Medicine·Anne F WilliamsChristine J Moffatt
Feb 24, 2006·Annals of Surgery·Corinne BeckerGeneviève Hidden
Jul 13, 2006·PLoS Medicine·Raymond TabibiazarStanley G Rockson
Dec 21, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Lauren CheungStanley G Rockson
May 5, 2007·Annals of Surgical Oncology·Margaret ThompsonV Suzanne Klimberg

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Citations

Mar 21, 2009·Breast Cancer Research and Treatment·K S BlumR Pabst
Mar 16, 2012·Lymphatic Research and Biology·Tanja SommerCatarina Hadamitzky
Dec 3, 2010·Plastic and Reconstructive Surgery·Hiroo Suami, David W Chang
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·Chin-Yu YangMing-Huei Cheng
Oct 1, 2014·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Catarina HadamitzkyPeter M Vogt
Jun 28, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·C HadamitzkyC Radtke
Aug 4, 2015·The Journal of Surgical Research·Florian S FruehPietro Giovanoli
Jun 22, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A SchmiedlM Stephan
Mar 16, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tanja SommerReinhard Pabst
Apr 25, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Miguel A Soto-MirandaDavid W Chang
Oct 31, 2013·International Journal of Dermatology·Tara NekoroskiGilbert-A Keller
May 7, 2016·Cell Biochemistry and Function·Joomin LeeSeyeon Park
Jan 21, 2017·International Journal of Molecular Sciences·Catherine L LyBabak J Mehrara
Aug 2, 2017·Lymphatic Research and Biology·Randolfo Fernández PeñuelaJaume Masiá Ayala
Feb 2, 2011·Circulation·Markku LähteenvuoAnne Saaristo
Jul 12, 2018·Annals of Plastic Surgery·Mads Gustaf JørgensenJens Ahm Sørensen
Jun 2, 2017·Annals of Plastic Surgery·Corrado Cesare CampisiMihai Ionac
Jun 16, 2021·Advances in Wound Care·Jerry F HsuAlex K Wong
Jun 24, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Lucian P JigaJanniko Georgiadis

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