Abstract
We describe a previously healthy boy who developed intestinal pseudo-obstruction following an episode of gastroenteritis at age 2 years. At presentation, the patient had mildly raised erythrocyte sedimentation rate and C-reactive protein level, and elevated antineutrophil cytoplasmic antibodies, antinuclear anti-DNA, and anti-smooth muscle antibodies. His electrogastrography was myopathic with no dominant frequency. First full-thickness intestinal biopsies showed a T lymphocytic myositis, particularly in the circular muscle. Steroid therapy resulted in clinical remission; cessation of steroids, in relapse. Further full-thickness biopsies showed an initial reduction in alpha-smooth muscle actin immunostaining in circular muscle myocytes and later atrophy and disappearance of many myocytes. Vascular and the remaining enteric smooth muscle cells showed HLA-DR and intercellular adhesion molecule 1 expression. These observations demonstrate the ability of enteric myocytes to take part in an inflammatory response and to change their phenotype, allowing them to act as antigen-presenting cells and to activate T cells. This and possible cytokine production by the myocytes play a role in their own destruction. This process responded to i...Continue Reading
References
Nov 1, 1992·Gut·S P DevaneP J Milla
Dec 1, 1992·Histopathology·V V SmithR J Nicholls
Aug 1, 1987·Gut·M F KagnoffR K Austin
May 1, 1980·Gut·W J SnapeS Cohen
Jun 1, 1995·Gastroenterology·I KhanS M Collins
May 1, 1996·Gastroenterology·C M HogaboamS M Collins
Apr 1, 1997·Gastroenterology·V V SmithP J Milla
Aug 1, 1997·Histopathology·V V Smith, P J Milla
Jan 1, 1998·Gut·S D MannM A Kamm
Jan 27, 1998·Journal of Pediatric Gastroenterology and Nutrition·A M Ravelli, P J Milla
Jun 18, 1999·Archives of Disease in Childhood·S HeneykeP J Milla
Sep 29, 1999·Gastroenterology·J C GoinE Borda
Dec 29, 2000·Lancet·S P RigbyM A Kamm
May 4, 2001·Journal of Autoimmunity·A P Moran, M M Prendergast
Jul 17, 2001·Liver·D P BogdanosD Vergani
Citations
Nov 27, 2015·Journal of Veterinary Internal Medicine·A C ZacutoS L Marks
Oct 22, 2008·Progress in Neurobiology·Andrew HubballCharles H Knowles
Oct 4, 2015·Gastroenterology·Michael KrissBlair Fennimore
Aug 29, 2014·Acta Physiologica·F ChenY Li
Apr 10, 2016·Developmental Biology·Allan M GoldsteinRoberto De Giorgio
May 29, 2004·Journal of Pediatric Gastroenterology and Nutrition·Peter J Milla
Sep 26, 2015·Lupus·Q HuangM Yang
Jan 2, 2007·Veterinary Pathology·C S JohnsonJ S Haynes
Jan 10, 2009·World Journal of Gastroenterology : WJG·Charles H Knowles, Joanne E Martin
Mar 24, 2018·Journal of Pediatric Gastroenterology and Nutrition·Nikhil ThaparCarlo Di Lorenzo
Aug 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Virpi V SmithKeith J Lindley
Feb 7, 2008·Journal of Pediatric Gastroenterology and Nutrition·Virpi V Smith
Feb 7, 2008·Journal of Pediatric Gastroenterology and Nutrition·Nikhil Thapar
Mar 28, 2008·Journal of Pediatric Gastroenterology and Nutrition·Alessandra MartinRoberto De Giorgio
Feb 7, 2008·Journal of Pediatric Gastroenterology and Nutrition·Charles H Knowles
Apr 11, 2009·Acta Neuropathologica·Charles H KnowlesThilo Wedel
Sep 18, 2004·The Proceedings of the Nutrition Society·D B A Silk
Feb 27, 2013·Der Pathologe·E BruderW A Meier-Ruge
Dec 19, 2019·Current Gastroenterology Reports·Heidi E Gamboa, Manu Sood
Oct 5, 2018·Toxicologic Pathology·Susan A ElmoreCynthia J Willson
Nov 11, 2020·JCI Insight·Nathaniel W YorkColin G Nichols
Sep 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Carlo Di Lorenzo
Mar 4, 2021·Journal of Cellular and Molecular Medicine·Delphine MartirePascal de Santa Barbara
Apr 13, 2021·Zeitschrift für Gastroenterologie·Bismark Osei SarfoGötz von Wichert