Acquired Natural Killer Cell Dysfunction in the Tumor Microenvironment of Classic Hodgkin Lymphoma

Frontiers in Immunology
Jodi ChiuArmand Keating

Abstract

An understanding of interactions within the tumor microenvironment (TME) of classic Hodgkin lymphoma (cHL) has helped pave the way to novel immunotherapies that have enabled dormant and tumor-tolerant immune cells to be reactivated. The immunosuppressive nature of the TME in cHL specifically inhibits the proliferation and activity of natural killer (NK) cells, which contributes to tumor immune-escape mechanisms. This deficiency of NK cells begins at the tumor site and progresses systemically in patients with advanced disease or adverse prognostic factors. Several facets of cHL account for this effect on NK cells. Locally, malignant Reed-Sternberg cells and cells from the TME express ligands for inhibitory receptors on NK cells, including HLA-E, HLA-G, and programmed death-ligand 1. The secretion of chemokines and cytokines, including soluble IL-2 receptor (sCD25), Transforming Growth Factor-β, IL-10, CXCL9, and CXCL10, mediates the systemic immunosuppression. This review also discusses the potential reversibility of quantitative and functional NK cell deficiencies in cHL that are likely to lead to novel treatments.

References

Jan 21, 1992·International Journal of Cancer. Journal International Du Cancer·R N DamleS G Gangal
Aug 1, 1990·British Journal of Cancer·N RajaramS G Gangal
Jul 1, 1985·European Journal of Cancer & Clinical Oncology·F HealyB W Hancock
Jul 1, 1984·Journal of Clinical Pathology·C S Morris, A E Stuart
Nov 1, 1982·European Journal of Cancer & Clinical Oncology·C M HawrylowiczC W Potter
Feb 7, 1997·International Journal of Cancer. Journal International Du Cancer·S L GlaserA Claviez
Sep 9, 1999·Journal of Reproductive Immunology·C CantoniR Biassoni
Jun 1, 2000·Leukemia & Lymphoma·J Teruya-FeldsteinE S Jaffe
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T K YuE A Grimm
Feb 27, 2001·The American Journal of Surgical Pathology·C S VerbekeH Zentgraf
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J J CampbellE C Butcher
Jul 17, 2001·Journal of Hematotherapy & Stem Cell Research·G MakiY K Tam
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Ewerton M MaggioSibrand Poppema
Mar 22, 2003·Lancet·Lynny Yung, David Linch
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martina SchröderGerald Grütz
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari StrengellTimo Sareneva
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mitsunori ShiroishiKatsumi Maenaka
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Berthe M P AlemanFlora E van Leeuwen
Apr 14, 2004·The Journal of Experimental Medicine·Stephan MathasBernd Dörken
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·June-Chul LeeDae Seog Heo
Nov 9, 2004·Nature Immunology·Alfonso Martín-FontechaFederica Sallusto
Nov 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guido FerlazzoChristian Münz
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xia WuDa-Jin Li
Sep 28, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Theresa H M KeeganRichard F Ambinder
Mar 1, 2006·The Journal of Experimental Medicine·Marc BajénoffNicolas Glaichenhaus

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Citations

Apr 18, 2019·Journal of Cellular Physiology·Behnaz ValipourHojjatollah Nozad Charoudeh
May 21, 2019·Therapeutic Advances in Hematology·Nicole A Carreau, Catherine S Diefenbach
Nov 12, 2019·Cell Biochemistry and Function·Yizhen LiuXiaojian Liu
Apr 14, 2018·Pathogens·Geok Wee TanArjan Diepstra
Feb 17, 2019·Journal of the International Society of Sports Nutrition·A JuszkiewiczA Skarpańska-Stejnborn
Aug 14, 2018·Frontiers in Oncology·Deepika Kumar, Mina L Xu
Mar 11, 2020·Frontiers in Immunology·Aviad Ben-ShmuelMira Barda-Saad
Dec 26, 2018·International Journal of Molecular Sciences·Rosanna VillaniGaetano Serviddio
Nov 7, 2019·International Journal of Molecular Sciences·Eleonora CalabrettaCarmelo Carlo-Stella
Dec 8, 2020·Leukemia & Lymphoma·Jorge Vela-OjedaLaura Arcelia Montiel-Cervantes
Oct 3, 2020·Transplantation and Cellular Therapy·Carlos E SanchezConrad Russell Y Cruz
Jun 3, 2020·Advances in Anatomic Pathology·Stephanie N Hurwitz, Adam Bagg
Jun 5, 2020·The Cancer Journal·Arushi Khurana, Stephen M Ansell
Feb 20, 2021·Leukemia & Lymphoma·Sanjal Desai, Stephen M Ansell
Mar 27, 2021·Stem Cell Research & Therapy·Margaret G LambDean A Lee
Apr 4, 2021·International Journal of Molecular Sciences·Clifford M Csizmar, Stephen M Ansell
Apr 6, 2021·Frontiers in Immunology·Zarema AlbakovaAlexander Sapozhnikov
May 25, 2021·ACS Applied Nano Materials·Lorena P Suarez-KellyWilliam E Carson
Jun 29, 2021·Seminars in Cancer Biology·Diego M Avella PatinoJonathan B Mitchem
Jun 29, 2021·Frontiers in Oncology·Faroogh MarofiMostafa Jarahian
May 15, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lucila N KerbauyKatayoun Rezvani

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Methods Mentioned

BETA
biopsies
exome sequencing

Clinical Trials Mentioned

NCT02321592

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